Bay 41-4109

Product Name: Bay 41-4109
CAS No.: 298708-81-3
Chemical Name: Bay 41-4109
Synonyms: Bay 41-4109;Bayer 41-4109;(±)-BAY 41-4109;Bay 41 4109,Bay 414109;BAY-41-4109 (R-isomer);BAY41-4109; BAY-41-4109; BAYER 41-4109;methyl (R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate;5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4R)-
CBNumber: CB03169580
Molecular Formula: C18H13ClF3N3O2
Formula Weight: 395.76
MOL File: 298708-81-3.mol

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Bay 41-4109 Property

Boiling point:: 475.3±45.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (252.68 mM);Water : < 0.1 mg/mL (insoluble)
pka: 5.43±0.60(Predicted)
form: Solid
color: Light yellow to yellow
InChI: 1S/C18H13ClF3N3O2/c1-8-14(18(26)27-2)15(11-4-3-9(20)5-12(11)19)25-17(24-8)16-13(22)6-10(21)7-23-16/h3-7,15H,1-2H3,(H,24,25)/t15-/m0/s1
InChIKey: FVNJBPMQWSIGJK-HNNXBMFYSA-N
SMILES: CC1=C(C(OC)=O)[C@H](C2=C(Cl)C=C(F)C=C2)N=C(C3=NC=C(F)C=C3F)N1

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2444
Product name: BAY 41-4109
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $106.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2444
Product name: BAY 41-4109
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $449
Updated: 2025/07/31

ChemScene

Product number: CS-6426
Product name: BAY 41-4109
Purity: 98.39%
Packaging: 1mg
Price: $264
Updated: 2021/12/16

ChemScene

Product number: CS-6426
Product name: BAY 41-4109
Purity: 98.39%
Packaging: 5mg
Price: $792
Updated: 2021/12/16

ChemScene

Product number: CS-6426
Product name: BAY 41-4109
Purity: 98.39%
Packaging: 10mg
Price: $1200
Updated: 2021/12/16

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Bay 41-4109 Chemical Properties,Usage,Production

Uses

BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.

Biological Activity

BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with IC50 value of 53 nM.

in vivo

BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice.

target

IC50&Target: 53 nM (HBV)

References

[1] Weber O, et al. Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model. Antiviral Res. 2002 May;54(2):69-78. DOI:10.1016/s0166-3542(01)00216-9
[2] Stray SJ, et al. BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly. J Mol Recognit. 2006 Nov-Dec;19(6):542-8. DOI:10.1002/jmr.801
[3] Wu GY, et al. Inhibition of hepatitis B virus replication by Bay 41-4109 and its association with nucleocapsid disassembly. J Chemother. 2008 Aug;20(4):458-67. DOI:10.1179/joc.2008.20.4.458

Bay 41-4109 Preparation Products And Raw materials

Raw materials

Preparation Products

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Bay 41-4109 Suppliers

China 35 United States 6 Global 41

Shanghai YuanYe Biotechnology Co., Ltd.

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298708-81-3, Bay 41-4109Related Search:

Bay 41-4109

methyl (R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate

BAY41-4109; BAY-41-4109; BAYER 41-4109

Bayer 41-4109

5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4R)-

BAY-41-4109 (R-isomer)

Bay 41 4109,Bay 414109

(±)-BAY 41-4109

298708-81-3