3-Methylthio-1,2,4-triazine
- Product Name
- 3-Methylthio-1,2,4-triazine
- CAS No.
- 28735-21-9
- Chemical Name
- 3-Methylthio-1,2,4-triazine
- Synonyms
- 3-(Methylthio)-as-Triazine;3-METHYLTHIO-1,2,4-TRIAZINE;3-(Methylthio)-2,4-triazine;1,2,4-Triazine, 3-(Methylthio)-;3-(Methylsulfanyl)-1,2,4-triazine;METHYL 1,2,4-TRIAZIN-3-YL SULFIDE;3-Methylthio-1,2,4-triazine ISO 9001：2015 REACH
- CBNumber
- CB0317993
- Molecular Formula
- C4H5N3S
- Formula Weight
- 127.17
- MOL File
- 28735-21-9.mol
3-Methylthio-1,2,4-triazine Property
- Melting point:
- 33 °C
- Boiling point:
- 275.8±23.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 1.32±0.63(Predicted)
- Appearance
- Yellow to brown <33°C Solid,>33°C Liquid
- InChI
- InChI=1S/C4H5N3S/c1-8-4-5-2-3-6-7-4/h2-3H,1H3
- InChIKey
- NFHGWQLAJYTULJ-UHFFFAOYSA-N
- SMILES
- N1C=CN=C(SC)N=1
- CAS DataBase Reference
- 28735-21-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SYX00362
- Product name
- 3-(Methylthio)-2,4-triazine
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- M725558
- Product name
- 3-(Methylthio)-as-triazine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 070401
- Product name
- 3-(Methylthio)-2,4-triazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR961054
- Product name
- 3-Methylthio-1,2,4-triazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 070401
- Product name
- 3-(Methylthio)-2,4-triazine
- Purity
- 97%
- Packaging
- 5g
- Price
- $149
- Updated
- 2021/12/16
3-Methylthio-1,2,4-triazine Chemical Properties,Usage,Production
Uses
3-Methylthio-1,2,4-triazine has a phenyl ring and has been shown to be pde5 inhibitory. 3-Methylthio-1,2,4-triazine was treated with potassium amide in liquid ammonia to give 3-amino-1,2,4-triazine, 3,3′-bis(methylthio)-5,5′-bis-1,2,4-triazine and 3-amino-3′-(methylthio)-5,5′-bis-1,2,4-triazine. triazine, 3,3′-bis(methylthio)-5,5′-bis-1,2,4-triazine and 3-amino-3′-(methylthio)-5,5′-bis-1,2,4-triazine. It is also used in the preparation of pharmaceutical products.
Synthesis
131543-46-9
35600-34-1
28735-21-9
The general procedure for the synthesis of 3-(methylthio)-α-triazine from 3-methylthioalkyl-1,2,4-triazine methylhydrazinylideneamino thiosulfate hydrogen iodide (Intermediate 16, 8.5 g, 32.18 mmol) and 40% oxalyl aldehyde (14.70 mL, 128.71 mmol) was as follows: an ice/water (400 mL) solution of Intermediate 16 was added to a 40% oxaldehyde solution with stirring. Subsequently, an ice/water (400 mL) solution of sodium bicarbonate (6.76 g, 80.45 mmol) cooled to 0°C was stirred at 0°C for 5 hours. After completion of the reaction, the reaction mixture was extracted with dichloromethane (DCM, 2 x 150 mL). The organic phases were combined, washed with 1 M citric acid (50 mL), dried over anhydrous magnesium sulfate (MgSO4), and concentrated under reduced pressure to afford 3-methylthioalkyl-1,2,4-triazine (3.60 g, 88% yield) as a yellow solid. The product was characterized by 1H NMR (400 MHz, CDCl3, 27 °C): δ 2.68 (3H, s), 8.38 (1H, d), 8.94 (1H, d).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 20, p. 6024 - 6029
[2] Tetrahedron Letters, 1986, vol. 27, # 4, p. 431 - 432
[3] Patent: US2017/152255, 2017, A1. Location in patent: Paragraph 0294; 0295
[4] Tetrahedron Letters, 1987, vol. 28, # 4, p. 379 - 382
3-Methylthio-1,2,4-triazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Methylthio-1,2,4-triazine manufacturers
- Product
- 3-Methylthio-1,2,4-triazine 28735-21-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 2000
- Release date
- 2025-09-03
- Product
- 3-Methylthio-1,2,4-triazine 28735-21-9
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 3-Methylthio-1,2,4-triazine 28735-21-9
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20