1H-Isoindole-1,3(2H)-dione, 2-[(acetyloxy)methyl]-
- Product Name
- 1H-Isoindole-1,3(2H)-dione, 2-[(acetyloxy)methyl]-
- CAS No.
- 5493-24-3
- Chemical Name
- 1H-Isoindole-1,3(2H)-dione, 2-[(acetyloxy)methyl]-
- Synonyms
- (1,3-dioxoisoindol-2-yl)methyl acetate;(1,3-Dioxoisoindolin-2-yl)methyl acetate;1-(1,3-dioxoisoindolin-2-yl)methyl acetate;(1,3-Dioxoisoindolin-2-yl)acetic acid methyl ester;1H-Isoindole-1,3(2H)-dione, 2-[(acetyloxy)methyl]-
- CBNumber
- CB03213193
- Molecular Formula
- C11H9NO4
- Formula Weight
- 219.19
- MOL File
- 5493-24-3.mol
1H-Isoindole-1,3(2H)-dione, 2-[(acetyloxy)methyl]- Property
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FD143079
- Product name
- (1,3-Dioxoisoindolin-2-yl)methyl acetate
- Packaging
- 1g
- Price
- $154
- Updated
- 2021/12/16
- Product number
- 2153CN
- Product name
- (1,3-Dioxoisoindolin-2-yl)methylacetate
- Packaging
- 1g
- Price
- $178
- Updated
- 2021/12/16
- Product number
- FD143079
- Product name
- (1,3-Dioxoisoindolin-2-yl)methyl acetate
- Packaging
- 2g
- Price
- $267
- Updated
- 2021/12/16
- Product number
- FD143079
- Product name
- (1,3-Dioxoisoindolin-2-yl)methyl acetate
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FD143079
- Product name
- (1,3-Dioxoisoindolin-2-yl)methyl acetate
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
1H-Isoindole-1,3(2H)-dione, 2-[(acetyloxy)methyl]- Chemical Properties,Usage,Production
Synthesis
2439-85-2
13831-31-7
5493-24-3
At room temperature, 100 mmol of N-bromophthalimide (compound of Formula I) and 100 mmol of acetoxyacetyl chloride (compound of Formula II) were mixed with 16 mmol of catalyst (a mixture of 8 mmol of tetracarbonyldiborodiruthenium and 8 mmol of copper triphenylphosphine (Cu(PPh3)Br)). Subsequently, 140 mmol of acetoxyacetyl chloride, 30 mmol of p-toluenesulfonic acid (as an acidic compound) and 6 mmol of additive L dissolved in a mixed organic solvent of acetonitrile and 1,4-dioxane in a volume ratio of 2:10 were added to the reaction system. The reaction mixture was heated to 80°C and the reaction was stirred at this temperature for 10 hours. Upon completion of the reaction, the reaction system was filtered and the pH of the filtrate was adjusted to neutral with base. Subsequently, a decompression distillation was carried out and the residue was purified by silica gel column chromatography using an equal volume of a solvent mixture of chloroform and ethyl acetate as eluent. Finally, methyl (1,3-dioxoisoindolin-2-yl)acetate (compound of formula III, where Ac represents acetoxy) with a melting point of 109-110°C was obtained by decompression distillation in 90.8% yield.
References
[1] Patent: CN106432050, 2017, A. Location in patent: Paragraph 0030; 0031; 0032; 0033; 0034; 0040; 0041; 0042-44
1H-Isoindole-1,3(2H)-dione, 2-[(acetyloxy)methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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