3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
- Product Name
- 3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
- CAS No.
- 70678-95-4
- Chemical Name
- 3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
- Synonyms
- HO-PEG4-CH2COOH;Hydroxy-PEG4-CH2CO2H;Hydroxy-PEG4-CH2CO2H, sodium salt;14-hydroxy-3,6,9,12-tetraoxatetradecanoic acid;3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-;2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]aceticacid;HO-PEG4-CH2COOH/3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
- CBNumber
- CB03245444
- Molecular Formula
- C10H20O7
- Formula Weight
- 252.26
- MOL File
- 70678-95-4.mol
3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- Property
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- AS104049
- Product name
- HO-PEG4-CH2COOH
- Purity
- 95+%
- Packaging
- 1g
- Price
- $532
- Updated
- 2021/12/16
- Product number
- BP-23621
- Product name
- Hydroxy-PEG4-CH2CO2Hsodiumsalt
- Purity
- 97%
- Packaging
- 1g
- Price
- $540
- Updated
- 2021/12/16
3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- Chemical Properties,Usage,Production
Description
Hydroxy-PEG4-CH2CO2H, sodium salt, is a PEG derivative containing a hydroxyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
Uses
Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
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