ChemicalBook > CAS DataBase List > Acid-PEG2-t-butyl ester

Acid-PEG2-t-butyl ester

Product Name
Acid-PEG2-t-butyl ester
CAS No.
2086688-99-3
Chemical Name
Acid-PEG2-t-butyl ester
Synonyms
3-(2-(3-(tert-Butoxy)-3-oxopropoxy)ethoxy)propanoic acid;COOH-PEG2-OtBu;Acid-PEG2-C2-Boc;Acid-PEG2-t-Bu Ester;Acid-PEG2-t-butyl ester;t-butyl ester-PEG1-acid;3-[2-(2-Boc-ethoxy)ethoxy]propanoic Acid;3-[2-(2-Carboxyethoxy)ethoxy]propanoic acid tert-butyl ester;Propanoic acid, 3-[2-(2-carboxyethoxy)ethoxy]-, 1-(1,1-dimethylethyl) ester
CBNumber
CB03303326
Molecular Formula
C12H22O6
Formula Weight
262.3
MOL File
2086688-99-3.mol
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Acid-PEG2-t-butyl ester Property

Boiling point:
384.3±27.0 °C(Predicted)
Density 
1.104±0.06 g/cm3(Predicted)
storage temp. 
2-8°C, sealed storage, away from moisture
solubility 
Soluble in Water, DMSO, DMF
pka
4.27±0.10(Predicted)
form 
Liquid
color 
Colorless to light yellow
InChI
InChI=1S/C12H22O6/c1-12(2,3)18-11(15)5-7-17-9-8-16-6-4-10(13)14/h4-9H2,1-3H3,(H,13,14)
InChIKey
FVMOAKLTZMCDOV-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)CCOCCOCCC(O)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-23510
Product name
Acid-PEG2-t-butylester
Purity
98%
Packaging
100mg
Price
$380
Updated
2021/12/16
BroadPharm
Product number
BP-23510
Product name
Acid-PEG2-t-butylester
Purity
98%
Packaging
250mg
Price
$680
Updated
2021/12/16
BroadPharm
Product number
BP-23510
Product name
Acid-PEG2-t-butylester
Purity
98%
Packaging
500mg
Price
$980
Updated
2021/12/16
BroadPharm
Product number
BP-23510
Product name
Acid-PEG2-t-butylester
Purity
98%
Packaging
1g
Price
$1650
Updated
2021/12/16
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Acid-PEG2-t-butyl ester Chemical Properties,Usage,Production

Description

Acid-PEG2-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Acid-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Acid-PEG2-t-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Acid-PEG2-t-butyl ester Suppliers

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View Lastest Price from Acid-PEG2-t-butyl ester manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
COOH-PEG2-COOtBu 2086688-99-3
Price
US $0.00/g
Min. Order
1g
Purity
>98.00%
Supply Ability
1g
Release date
2024-03-23

2086688-99-3, Acid-PEG2-t-butyl esterRelated Search:

mPEG11-NHS Ester MPEG8-NHS mPEG10-NHS Ester m-PEG7-NHS ester m-PEG3-NHS ester COOH-PEG2-COOMe Acid-peg13-nhs ester COOH-PEG8-COOtBu COOH-PEG7-COOMe COOH-PEG9-COOMe COOH-PEG8-COOMe INDEX NAME NOT YET ASSIGNED 4,7,10,13,16,19,22-Heptaoxapentacosanedioic acid, 1-(1,1-dimethylethyl) ester COOH-PEG9-COOtBu COOH-PEG11-COOMe COOH-PEG12-COOMe COOH-PEG12-COOtBu COOH-PEG10-COOMe

  • t-butyl ester-PEG1-acid
  • Acid-PEG2-t-butyl ester
  • Acid-PEG2-C2-Boc
  • Propanoic acid, 3-[2-(2-carboxyethoxy)ethoxy]-, 1-(1,1-dimethylethyl) ester
  • COOH-PEG2-OtBu
  • 3-[2-(2-Carboxyethoxy)ethoxy]propanoic acid tert-butyl ester
  • 3-(2-(3-(tert-Butoxy)-3-oxopropoxy)ethoxy)propanoic acid
  • Acid-PEG2-t-Bu Ester
  • 3-[2-(2-Boc-ethoxy)ethoxy]propanoic Acid
  • 2086688-99-3
  • peg