ChemicalBook > CAS DataBase List > DSR 6434
DSR 6434
- Product Name
- DSR 6434
- CAS No.
- 1059070-10-8
- Chemical Name
- DSR 6434
- Synonyms
- DSR 6434;DSR6434,DSR 6434;6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one;6-Amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-
- CBNumber
- CB03310328
- Molecular Formula
- C19H28N8O2
- Formula Weight
- 400.48
- MOL File
- 1059070-10-8.mol
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DSR 6434 Property
- Density
- 1.283±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:145.03(Max Conc. mg/mL);362.12(Max Conc. mM)
- form
- A solid
- pka
- 10.22±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Tocris
- Product number
- 4809
- Product name
- DSR6434
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $219
- Updated
- 2021/12/16
Tocris
- Product number
- 4809
- Product name
- DSR6434
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $918
- Updated
- 2021/12/16
Usbiological
- Product number
- 255202
- Product name
- DSR 6434
- Packaging
- 10mg
- Price
- $475
- Updated
- 2021/12/16
TRC
- Product number
- C982610
- Product name
- DSR6434
- Packaging
- 10mg
- Price
- $200
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0032972
- Product name
- DSR-6434
- Purity
- 99.49%
- Packaging
- 50mg
- Price
- $900
- Updated
- 2021/12/16
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DSR 6434 Chemical Properties,Usage,Production
Uses
DSR 6434 (cas# 1059070-10-8) is a useful research chemical.DSR is a TLR7 agonist. DSR 6434 indicated an optimal balance between the agonistic potency and high water solubility.
Biological Activity
DSR 6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist with EC50 of 7.2 nM and 4.6 nM for human and mouse TLR7, respectively. It has strong antitumor effect.
in vitro
To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation.
target
| TLR7 7.2 nM (EC 50 , Human) | TLR7 4.6 nM (EC 50 , Mice) |
storage
Store at -20°C
DSR 6434 Preparation Products And Raw materials
Raw materials
Preparation Products
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