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DSR 6434

Product Name
DSR 6434
CAS No.
1059070-10-8
Chemical Name
DSR 6434
Synonyms
DSR 6434;DSR6434,DSR 6434;6-amino-2-(butylamino)-9-({6-[2-(dimethylamino)ethoxy]pyridin-3-yl}methyl)-8,9-dihydro-7H-purin-8-one;6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one;6-Amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-
CBNumber
CB03310328
Molecular Formula
C19H28N8O2
Formula Weight
400.48
MOL File
1059070-10-8.mol
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DSR 6434 Property

Density 
1.283±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:145.03(Max Conc. mg/mL);362.12(Max Conc. mM)
form 
A solid
pka
10.22±0.20(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
4809
Product name
DSR6434
Purity
≥98%(HPLC)
Packaging
10
Price
$219
Updated
2021/12/16
Tocris
Product number
4809
Product name
DSR6434
Purity
≥98%(HPLC)
Packaging
50
Price
$918
Updated
2021/12/16
Usbiological
Product number
255202
Product name
DSR 6434
Packaging
10mg
Price
$475
Updated
2021/12/16
TRC
Product number
C982610
Product name
DSR6434
Packaging
10mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0032972
Product name
DSR-6434
Purity
99.49%
Packaging
50mg
Price
$900
Updated
2021/12/16
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DSR 6434 Chemical Properties,Usage,Production

Uses

DSR 6434 (cas# 1059070-10-8) is a useful research chemical.DSR is a TLR7 agonist. DSR 6434 indicated an optimal balance between the agonistic potency and high water solubility.

Biological Activity

DSR 6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist with EC50 of 7.2 nM and 4.6 nM for human and mouse TLR7, respectively. It has strong antitumor effect.

in vitro

To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation.

target

TLR7

7.2 nM (EC 50 , Human)

TLR7

4.6 nM (EC 50 , Mice)

storage

Store at -20°C

DSR 6434 Preparation Products And Raw materials

Raw materials

Preparation Products

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DSR 6434 Suppliers

China 30 United Kingdom 1 United States 6 Global 37
Shanghai Lollane Biological Technology Co.,Ltd.
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1059070-10-8, DSR 6434Related Search:


  • DSR 6434
  • 6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one
  • 8H-Purin-8-one, 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-
  • 6-Amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one
  • DSR6434,DSR 6434
  • 6-amino-2-(butylamino)-9-({6-[2-(dimethylamino)ethoxy]pyridin-3-yl}methyl)-8,9-dihydro-7H-purin-8-one
  • 1059070-10-8
  • C19H28N8O2