ChemicalBook > CAS DataBase List > FX1

FX1

Product Name
FX1
CAS No.
1426138-42-2
Chemical Name
FX1
Synonyms
FX1;CS-2497;FX-1;FX 1;FX1（CS-2497）;FX1 >=98% (HPLC);inhibit,Apoptosis,Bcl-2 Family,FX 1,FX1,FX-1,Inhibitor;(Z)-3-(5-(5-chloro-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid;(5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid;3-Thiazolidinepropanoic acid, 5-(5-chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-, (5Z)-;3-{5-[(3Z)-5-chloro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-4-oxo-2-thioxo-1,3-thiazol-3-yl}propanoic acid
CBNumber
CB03312337
Molecular Formula
C14H9ClN2O4S2
Formula Weight
368.82
MOL File
1426138-42-2.mol
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FX1 Property

storage temp. 
2-8°C
solubility 
DMSO:24.22(Max Conc. mg/mL);65.67(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);81.34(Max Conc. mM)
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2074
Product name
FX1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$105
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2074
Product name
FX1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$254.4
Updated
2024/03/01
Cayman Chemical
Product number
23908
Product name
FX1
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23908
Product name
FX1
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
23908
Product name
FX1
Purity
≥95%
Packaging
10mg
Price
$169
Updated
2024/03/01
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FX1 Chemical Properties,Usage,Production

Uses

(5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic Acid is used in the preparation of substituted isatinylidenerhodanines. BCL6 inhibitor, an anticancer agent.

Definition

ChEBI: FX1 is a member of the class of oxindoles that is 5-chloro-oxindole in which the methylene hydrogens at position 3 have been replaced by an N-(2-carboxyethyl)rhodanin-5-ylidene group. It has a role as an antineoplastic agent. It is a member of oxindoles, an organochlorine compound, a thiazolidinone and a monocarboxylic acid. It is functionally related to a 3-methyleneoxindole and a rhodanine.

Biochem/physiol Actions

FX1 is a BCL6 inhibitor that effectively blocks BCL6 N-terminal BTB domain-mediated corepressors chromosome recruitment (by 61-87%/SMRT and 67-82%/BCOR; 50 μM FX1 for 30 min) and selectively suppresses BCL6-depenent growth (GI50 16-54 μM; >125 μM against BCL6-independent cells) in diffuse large B cell lymphoma (DLBCL) cultures, exhibiting greater affinity than its structure analog 79-6 or BCL6 corepressor SMRT for BTB domain (KD = 7 μM/FX1, 30 μM/SMRT, 129 μM/79-6). FX1 shows greater efficacy than 79-6 in reversing BCL6/corepressors-mediated target genes repression in vitro (IC50 = 35 μM vs. 318 μM with 79-6 by HEK293T-based reporter assay) and in suppressing OCI-Ly7 DLBCL xenograft tumor growth mice in vivo (100% vs. 45% suppression with respective compound via 25 mg/kg/day i.p.).

storage

Store at -20°C

FX1 Preparation Products And Raw materials

Raw materials

Preparation Products

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1426138-42-2, FX1Related Search:


  • FX1
  • FX-1;FX 1
  • CS-2497
  • (Z)-3-(5-(5-chloro-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid
  • (5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid
  • 3-Thiazolidinepropanoic acid, 5-(5-chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-, (5Z)-
  • FX1 >=98% (HPLC)
  • inhibit,Apoptosis,Bcl-2 Family,FX 1,FX1,FX-1,Inhibitor
  • FX1（CS-2497）
  • 3-{5-[(3Z)-5-chloro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-4-oxo-2-thioxo-1,3-thiazol-3-yl}propanoic acid
  • 1426138-42-2