2-(3-sulfanylpropyl)pentanedioic acid
- Product Name
- 2-(3-sulfanylpropyl)pentanedioic acid
- CAS No.
- 254737-29-6
- Chemical Name
- 2-(3-sulfanylpropyl)pentanedioic acid
- Synonyms
- 2-MPPA;2MPPA,2 MPPA;FNLNSQHJKVQCBP-UHFFFAOYSA-N;2-(3-Mercaptopropyl)pentanedioic acid;2-(3-sulfanylpropyl)pentanedioic acid;Pentanedioic acid, 2-(3-mercaptopropyl)-
- CBNumber
- CB03313172
- Molecular Formula
- C8H14O4S
- Formula Weight
- 206.26
- MOL File
- 254737-29-6.mol
2-(3-sulfanylpropyl)pentanedioic acid Property
- Melting point:
- 51-53 °C
- Boiling point:
- 377.124±32.00 °C(Press: 760.00 Torr)(predicted)
- Density
- 1.256±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble to 100 mM in water and to 100 mM in DMSO
- form
- Powder
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- 5033
- Product name
- 2-MPPA
- Packaging
- 10
- Price
- $202
- Updated
- 2021/12/16
- Product number
- 254369
- Product name
- 2-MPPA
- Packaging
- 10mg
- Price
- $522
- Updated
- 2021/12/16
- Product number
- M745810
- Product name
- 2-MPPA
- Packaging
- 100mg
- Price
- $1470
- Updated
- 2021/12/16
- Product number
- 71639
- Product name
- 2-MPPA
- Packaging
- 10mg
- Price
- $675
- Updated
- 2021/12/16
- Product number
- B7734
- Product name
- 2-MPPA
- Packaging
- 10mg
- Price
- $345
- Updated
- 2021/12/16
2-(3-sulfanylpropyl)pentanedioic acid Chemical Properties,Usage,Production
Uses
2-MPPA is a selective glutamate carboxypeptidase II (GCP-II) inhibitor used in the treatment of neurological disorders associated with excessive activation of glutamatergic systems. Attenuates glutamate transmission resulting in the relief of neuropathic pain. This compound has neuroprotective properties.
in vivo
2-MPPA (10, 30 or 100 mg/kg) significantly attenuates Dizocilpine (HY-15084B) (0.1 mg/kg)-induced prepulse inhibition (PPI) deficits in mice, in a dose dependent manner. The efficacy of 2-MPPA on dizocilpine-induced PPI deficits is significantly antagonized by pretreatment with the selective group II metabotropic glutamate receptor (mGluR) antagonist LY341495 (HY-70059) (1.0 mg/kg)[1].
2-MPPA (30 mg/kg) significantly prevents the deficit in SNCV induced by both 5 and 25 mg/kg taxol by 96.3 ± 4.4% and 98.3± 11.6% respectively[2].
2-MPPA (10 mg/kg) inhibits tumor growth in the high expressor PSMA model CWR22RS by 70%[2].
2-(3-sulfanylpropyl)pentanedioic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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