ChemicalBook > CAS DataBase List > (S)-Tetrahydro-2H-pyran-3-amine hydrochloride

(S)-Tetrahydro-2H-pyran-3-amine hydrochloride

Product Name
(S)-Tetrahydro-2H-pyran-3-amine hydrochloride
CAS No.
1245724-46-2
Chemical Name
(S)-Tetrahydro-2H-pyran-3-amine hydrochloride
Synonyms
(S)-TETRAHYDRO-2H-PYRAN-3-AMINE HCL;(S)-Tetrahydro-2H-pyran-3-amine hydrochloride;(S)-Tetrahydro-2H-pyran-3-amine 2hydrochloride;2H-Pyran-3-amine, tetrahydro-, hydrochloride (1:1), (3S)-;(S)-tetrahydro-2H-pyran-3-amine hydrochloride(WXC09058S1)
CBNumber
CB03333198
Molecular Formula
C5H12ClNO
Formula Weight
137.61
MOL File
1245724-46-2.mol
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(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Property

storage temp. 
Store at room temperature, keep dry and cool
Appearance
Off-white to light brown Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
CS-W018654
Product name
(S)-Tetrahydro-2H-pyran-3-aminehydrochloride
Packaging
1g
Price
$166
Updated
2021/12/16
Activate Scientific
Product number
AS26910-B
Product name
(S)-3-Aminotetrahydropyran HCl
Purity
96+% ee
Packaging
250mg
Price
$191
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0030640
Product name
(S)-TETRAHYDRO-2H-PYRAN-3-AMINE HYDROCHLORIDE
Purity
95.00%
Packaging
250MG
Price
$216.3
Updated
2021/12/16
Matrix Scientific
Product number
132367
Product name
(S)-Tetrahydro-2H-pyran-3-aminehydrochloride
Purity
97%
Packaging
1g
Price
$627
Updated
2021/12/16
Activate Scientific
Product number
AS26910-B
Product name
(S)-3-Aminotetrahydropyran HCl
Purity
96+% ee
Packaging
1g
Price
$425
Updated
2021/12/16
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(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Chemical Properties,Usage,Production

Synthesis

1295722-66-5

1245724-46-2

General procedure for the synthesis of (S)-3-aminotetrahydropyran hydrochloride from the compound (CAS: 1295722-66-5): the intermediate (S)-tert-butyltetrahydro-2H-pyran-3-ylcarbamate (414 g, 2.06 mol) was added to a methanolic solution (4 L) of 6 N HCl, and the reaction mixture was stirred at room temperature until the reaction was complete (monitored by TLC monitoring). Upon completion of the reaction, the mixture was concentrated under vacuum to afford 283 g of (S)-(tetrahydropyran-3-yl)amine hydrochloride as a white solid (99.8% yield, enantiomeric excess >99%). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.37 (s, 3H), 3.87-3.72 (m, 1H), 3.70-3.57 (m, 1H), 3.54-3.38 (m, 2H), 3.12 (d, J = 2.1 Hz, 1H), 2.05-1.89 (m, 1H), 1.81 -1.60 (m, 2H), 1.49 (dtd, J = 12.5, 8.3, 4.3 Hz, 1H).

References

[1] Patent: WO2013/7768, 2013, A1. Location in patent: Page/Page column 110; 111
[2] Synlett, 2013, vol. 24, # 8, p. 987 - 990

(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Suppliers

PharmaBlock Sciences (Nanjing),Inc.
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1245724-46-2, (S)-Tetrahydro-2H-pyran-3-amine hydrochlorideRelated Search:


  • (S)-Tetrahydro-2H-pyran-3-amine hydrochloride
  • (S)-TETRAHYDRO-2H-PYRAN-3-AMINE HCL
  • (S)-tetrahydro-2H-pyran-3-amine hydrochloride(WXC09058S1)
  • (S)-Tetrahydro-2H-pyran-3-amine 2hydrochloride
  • 2H-Pyran-3-amine, tetrahydro-, hydrochloride (1:1), (3S)-
  • 1245724-46-2