(S)-Tetrahydro-2H-pyran-3-amine hydrochloride
- Product Name
- (S)-Tetrahydro-2H-pyran-3-amine hydrochloride
- CAS No.
- 1245724-46-2
- Chemical Name
- (S)-Tetrahydro-2H-pyran-3-amine hydrochloride
- Synonyms
- (S)-TETRAHYDRO-2H-PYRAN-3-AMINE HCL;(S)-Tetrahydro-2H-pyran-3-amine hydrochloride;(S)-Tetrahydro-2H-pyran-3-amine 2hydrochloride;2H-Pyran-3-amine, tetrahydro-, hydrochloride (1:1), (3S)-;(S)-tetrahydro-2H-pyran-3-amine hydrochloride(WXC09058S1)
- CBNumber
- CB03333198
- Molecular Formula
- C5H12ClNO
- Formula Weight
- 137.61
- MOL File
- 1245724-46-2.mol
(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Property
- storage temp.
- Store at room temperature, keep dry and cool
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-W018654
- Product name
- (S)-Tetrahydro-2H-pyran-3-aminehydrochloride
- Packaging
- 1g
- Price
- $166
- Updated
- 2021/12/16
- Product number
- AS26910-B
- Product name
- (S)-3-Aminotetrahydropyran HCl
- Purity
- 96+% ee
- Packaging
- 250mg
- Price
- $191
- Updated
- 2021/12/16
- Product number
- CCH0030640
- Product name
- (S)-TETRAHYDRO-2H-PYRAN-3-AMINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $216.3
- Updated
- 2021/12/16
- Product number
- 132367
- Product name
- (S)-Tetrahydro-2H-pyran-3-aminehydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $627
- Updated
- 2021/12/16
- Product number
- AS26910-B
- Product name
- (S)-3-Aminotetrahydropyran HCl
- Purity
- 96+% ee
- Packaging
- 1g
- Price
- $425
- Updated
- 2021/12/16
(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Chemical Properties,Usage,Production
Synthesis
1295722-66-5
1245724-46-2
General procedure for the synthesis of (S)-3-aminotetrahydropyran hydrochloride from the compound (CAS: 1295722-66-5): the intermediate (S)-tert-butyltetrahydro-2H-pyran-3-ylcarbamate (414 g, 2.06 mol) was added to a methanolic solution (4 L) of 6 N HCl, and the reaction mixture was stirred at room temperature until the reaction was complete (monitored by TLC monitoring). Upon completion of the reaction, the mixture was concentrated under vacuum to afford 283 g of (S)-(tetrahydropyran-3-yl)amine hydrochloride as a white solid (99.8% yield, enantiomeric excess >99%). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.37 (s, 3H), 3.87-3.72 (m, 1H), 3.70-3.57 (m, 1H), 3.54-3.38 (m, 2H), 3.12 (d, J = 2.1 Hz, 1H), 2.05-1.89 (m, 1H), 1.81 -1.60 (m, 2H), 1.49 (dtd, J = 12.5, 8.3, 4.3 Hz, 1H).
References
[1] Patent: WO2013/7768, 2013, A1. Location in patent: Page/Page column 110; 111
[2] Synlett, 2013, vol. 24, # 8, p. 987 - 990
(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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