5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine

Product Name: 5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine
CAS No.: 2305415-75-0
Chemical Name: 5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine
Synonyms: 5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine;5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine
CBNumber: CB03334281
Molecular Formula: C10H11N5O5
Formula Weight: 281.23
MOL File: 2305415-75-0.mol

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Hazard and Precautionary Statements (GHS)

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5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine Chemical Properties,Usage,Production

Uses

5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine Preparation Products And Raw materials

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5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine Suppliers

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5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine

5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine

2305415-75-0