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G1T28

Product Name
G1T28
CAS No.
1977495-97-8
Chemical Name
G1T28
Synonyms
G1T28;Trilaciclib HCl;Trilaciclib DiHCl;G1T28 hydrochloride;Trasylide hydrochloride;Trilaciclib hydrochloride;Trilaciclib dihydrochloride;Tranexacile Dihydrochloride;Trilaciclib hydrochloride(G1T28);Trilaciclib Impurity(Dihydrochloride)
CBNumber
CB03335415
Molecular Formula
C24H31ClN8O
Formula Weight
483.02
MOL File
1977495-97-8.mol
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G1T28 Property

storage temp. 
Store at -20°C
solubility 
Ethanol: Slightly solublePBS (pH 7.2): Slightly soluble
form 
Solid
color 
Light yellow to yellow
Water Solubility 
Water : ≥ 100 mg/mL (192.50 mM)
InChIKey
KZNCPACHGMMKHH-UHFFFAOYSA-N
SMILES
O=C1NCC2(CCCCC2)N2C3=NC(NC4N=CC(N5CCN(C)CC5)=CC=4)=NC=C3C=C12.Cl
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7942
Product name
Trilaciclib(hydrochloride)
Purity
99.24%
Packaging
5mg
Price
$700
Updated
2021/12/16
ChemScene
Product number
CS-7942
Product name
Trilaciclib(hydrochloride)
Purity
99.24%
Packaging
10mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-7942
Product name
Trilaciclib(hydrochloride)
Purity
99.24%
Packaging
100mg
Price
$2400
Updated
2021/12/16
DC Chemicals
Product number
DC21033
Product name
Trilaciclibhydrochloride(G1T28)
Purity
>98%
Packaging
100mg
Price
$800
Updated
2021/12/16
DC Chemicals
Product number
DC21033
Product name
Trilaciclibhydrochloride(G1T28)
Purity
>98%
Packaging
250mg
Price
$1500
Updated
2021/12/16
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G1T28 Chemical Properties,Usage,Production

Uses

Trilaciclib (G1T28) hydrochloride is an orally active CDK4/6 inhibitor with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively. Trilaciclib hydrochloride can effectively inhibit tumor cell proliferation and reduce the hematological toxicity caused by chemotherapy. Trilaciclib hydrochloride attenuates apoptosis and myelosuppression induced by 5FU (HY-90006) chemotherapy[1].

in vivo

Trilaciclib hydrochloride (50-150 mg/kg; po; single dose) protects mouse bone marrow cells from chemotherapy-induced apoptosis and attenuates chemotherapy-induced myelosuppression in vivo. Trilaciclib hydrochloride at 150 mg/kg reduces HSPC damage induced by 5FU (150 mg/kg; ip) chemotherapy, thereby accelerating blood count recovery after chemotherapy[1].

Animal Model:FVB/n female C57Bl6 mice[1]
Dosage:50, 100, 150 mg/kg
Administration:Po; single dose; treated followed 11 or 23 hours later by a single injection of EdU (HY-118411) (100 μg; ip); mouse were euthanized 1 hour after EdU injection.
Result:Showed a dose-dependent decrease in caspase 3/7 activation.
Attenuated chemotherapy-induced myelosuppression in mice.

IC 50

Cdk4/cyclin D1: 1 nM (IC50); cdk6/cyclin D3: 4 nM (IC50)

References

[1] Bisi JE, et al. Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression. Mol Cancer Ther. 2016 May;15(5):783-93. DOI:10.1158/1535-7163.MCT-15-0775

G1T28 Preparation Products And Raw materials

Raw materials

Preparation Products

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G1T28 Suppliers

China 78 India 2 United States 3 Global 83
Nanjing Vcare PharmaTech Co., Ltd
Tel
025-58741518 13327700685
Email
sales@vcarepharmatech.com
Country
China
ProdList
486
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
28-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
510
Advantage
57
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1111
Advantage
64
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097 15801866362;
Email
info@topbiochem.com
Country
China
ProdList
9520
Advantage
58
AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
15928766785 15928766785
Fax
QQ961458712
Email
wupengcheng@astatech.cn
Country
China
ProdList
1988
Advantage
55
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
40000
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4798
Advantage
55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
8378
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
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View Lastest Price from G1T28 manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
Trilaciclib dihydrochloride 1977495-97-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-12-24
Shaanxi Dideu New Materials Co. Ltd
Product
G1T28 1977495-97-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-07

1977495-97-8, G1T28Related Search:


  • G1T28
  • Trilaciclib HCl
  • Trilaciclib hydrochloride
  • G1T28 hydrochloride
  • 2'-[[5-(4-Methylpiperazin-1-yl)pyridin-2-yl]amino}-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one, hydrochloride (1:2)
  • Trilaciclib hydrochloride(G1T28)
  • Trilaciclib dihydrochloride
  • 2'-((5-(4-Methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one dihydrochloride
  • Inhibitor,Trilaciclib hydrochloride,CDK,Cyclin dependent kinase,inhibit,Trilaciclib,G1T28
  • 12'-{[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino}-2',5',11',13'-tetraazaspiro[cyclohexane-1,3'-tricyclo[7.4.0.02,?]tridecane]-1'(9'),7',10',12'-tetraen-6'-one dihydrochloride
  • Trasylide hydrochloride
  • Trilaciclib DiHCl
  • Trilaciclib Impurity(Dihydrochloride)
  • Tranexacile Dihydrochloride
  • 1977495-97-8