KDOAM-25

Product Name: KDOAM-25
CAS No.: 2230731-99-2
Chemical Name: KDOAM-25
Synonyms: KDOAM-25;KDOAM 25,KDOAM25;KDOAM-25 trihydrochloride;4-Pyridinecarboxamide, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-
CBNumber: CB03339897
Molecular Formula: C15H25N5O2
Formula Weight: 307.39
MOL File: 2230731-99-2.mol

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KDOAM-25 Property

Boiling point:: 478.6±45.0 °C(Predicted)
Density: 1.137±0.06 g/cm3(Predicted)
storage temp.: -20°C
pka: 15.03±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

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KDOAM-25 Chemical Properties,Usage,Production

Biochem/physiol Actions

KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells.

KDOAM-25 Preparation Products And Raw materials

Raw materials

Preparation Products

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KDOAM-25 Suppliers

China 11 United States 4 Global 15

Sigma-Aldrich

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DC Chemicals

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2230731-99-2, KDOAM-25Related Search:

KDOAM-25

4-Pyridinecarboxamide, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-

KDOAM-25 trihydrochloride

KDOAM 25,KDOAM25

2230731-99-2