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PF04191834

Product Name
PF04191834
CAS No.
1029317-21-2
Chemical Name
PF04191834
Synonyms
PF-4191834;PF04191834;PF-4191834 >=98% (HPLC);PF4191834,Lipoxygenase,PF 4191834,inhibit,LOX,PF 04191834,PF-4191834,PF04191834,Inhibitor;2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio]phenyl]-
CBNumber
CB03354232
Molecular Formula
C22H23N3O2S
Formula Weight
393.5
MOL File
1029317-21-2.mol
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PF04191834 Property

Melting point:
173 °C
Boiling point:
663.0±55.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
15.78±0.20(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0063590
Product name
PF-4191834
Purity
≥99.0%
Packaging
5mg
Price
$690
Updated
2021/12/16
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PF04191834 Chemical Properties,Usage,Production

Biological Activity

PF-4191834 (PF-04191834) is an orally active, non-iron-chelating, non-redox 5-lipoxygenase (5-LOX) inhibitor (IC50=229 nM), 5-LOX is about 300 times more selective than 12-LOX and 15-LOX, has no activity against cyclooxygenase, and is effective against inflammation and pain.

in vitro

PF-4191834 (PF-04191834) inhibits the synthesis of the 5-LOX products 5-HETE, 5-oxo-ETE, LTB4, and LTE4 with estimated IC 50 values between 100 and 190 nM and do not inhibit significantly the COX-1/2 enzymes or the 12- or 15-LOX enzymes at concentrations up to 30 μM. PF-4191834 (PF-04191834) exerts a concentration-dependent inhibition of human 5-LOX, with an IC 50 value of 130 nM and an IC 80 value of 370 nM.

target

5-LOX

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PF04191834 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF04191834 Suppliers

China 12 United States 3 Global 15
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1029317-21-2, PF04191834Related Search:

PF-06372222 PF-232798 PF-68742 PF-06882961

  • PF04191834
  • PF-4191834
  • 2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio]phenyl]-
  • PF-4191834 >=98% (HPLC)
  • PF4191834,Lipoxygenase,PF 4191834,inhibit,LOX,PF 04191834,PF-4191834,PF04191834,Inhibitor
  • 1029317-21-2