ChemicalBook > CAS DataBase List > inS3-54A18

inS3-54A18

Product Name
inS3-54A18
CAS No.
328998-53-4
Chemical Name
inS3-54A18
Synonyms
inS3-54A18;CID 1920398;inS3-54A18, 10 mM in DMSO;inS3-54A18,Inhibitor,inS-3-54A18,inS3 54A18,inS354A18,inhibit,STAT;3-(4-Chlorobenzylidene)-1-(4-hydroxyphenyl)-5-phenyl-1,3-dihydro-2H-pyrrol-2-one;2H-Pyrrol-2-one, 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-
CBNumber
CB03356160
Molecular Formula
C23H16ClNO2
Formula Weight
373.83
MOL File
328998-53-4.mol
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inS3-54A18 Property

Boiling point:
630.5±55.0 °C(Predicted)
Density 
1.363±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 150 mg/mL (401.25 mM)
form 
Solid
pka
10.05±0.30(Predicted)
color 
Yellow to orange
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7550
Product name
inS3-54A18
Purity
99.83%
Packaging
2mg
Price
$132
Updated
2021/12/16
ChemScene
Product number
CS-7550
Product name
inS3-54A18
Purity
99.83%
Packaging
5mg
Price
$192
Updated
2021/12/16
ChemScene
Product number
CS-7550
Product name
inS3-54A18
Purity
99.83%
Packaging
10mg
Price
$312
Updated
2021/12/16
ChemScene
Product number
CS-7550
Product name
inS3-54A18
Purity
99.83%
Packaging
50mg
Price
$1140
Updated
2021/12/16
ChemScene
Product number
CS-7550
Product name
inS3-54A18
Purity
99.83%
Packaging
100mg
Price
$1920
Updated
2021/12/16
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inS3-54A18 Chemical Properties,Usage,Production

Uses

inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.

in vivo

inS3-54A18 (200?mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells[1].

IC 50

STAT3

References

[1] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92. DOI:10.1038/onc.2015.215
[2] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92

inS3-54A18 Preparation Products And Raw materials

Raw materials

Preparation Products

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inS3-54A18 Suppliers

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328998-53-4, inS3-54A18Related Search:


  • inS3-54A18
  • 2H-Pyrrol-2-one, 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-
  • 3-(4-Chlorobenzylidene)-1-(4-hydroxyphenyl)-5-phenyl-1,3-dihydro-2H-pyrrol-2-one
  • inS3-54A18,Inhibitor,inS-3-54A18,inS3 54A18,inS354A18,inhibit,STAT
  • CID 1920398
  • inS3-54A18, 10 mM in DMSO
  • 328998-53-4