Cholesteryl hemisuccinate
- Product Name
- Cholesteryl hemisuccinate
- CAS No.
- 1510-21-0
- Chemical Name
- Cholesteryl hemisuccinate
- Synonyms
- CHOLESTERYL HYDROGEN SUCCINATE;cholesterylsuccinate;Cholesterol Succinate;CHOLESTERYL HEMISUCCINATE;MONO-CHOLESTERYL-SUCCINATE;CHOLESTEROL HYDROGEN SUCCINATE;5-CHOLESTEN-3β-OL HEMISUCCINATE;Cholesterol Hydrogen Succinate >5-CHOLESTEN-3-BETA-OL HEMISUCCINATE;SUCCINIC ACID MONOCHOLESTEROL ESTER
- CBNumber
- CB0336321
- Molecular Formula
- C31H50O4
- Formula Weight
- 486.73
- MOL File
- 1510-21-0.mol
Cholesteryl hemisuccinate Property
- Melting point:
- 178 °C
- Boiling point:
- 586.0±43.0 °C(Predicted)
- Density
- 1.06±0.1 g/cm3(Predicted)
- refractive index
- -34 ° (C=2, CHCl3)
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
- form
- Solid
- pka
- 4.40±0.17(Predicted)
- color
- White to Off-White
- InChIKey
- WLNARFZDISHUGS-BLYFUZNHSA-N
- LogP
- 10.708 (est)
- CAS DataBase Reference
- 1510-21-0(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- HS Code
- 29171900
N-Bromosuccinimide Price
- Product number
- C6512
- Product name
- Cholesteryl hemisuccinate
- Packaging
- 5g
- Price
- $271
- Updated
- 2024/03/01
- Product number
- C6512
- Product name
- Cholesteryl hemisuccinate
- Packaging
- 25g
- Price
- $897
- Updated
- 2024/03/01
- Product number
- 25698
- Product name
- Cholesteryl Hemisuccinate
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 25698
- Product name
- Cholesteryl Hemisuccinate
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $183
- Updated
- 2024/03/01
- Product number
- 25698
- Product name
- Cholesteryl Hemisuccinate
- Purity
- ≥95%
- Packaging
- 10g
- Price
- $341
- Updated
- 2024/03/01
Cholesteryl hemisuccinate Chemical Properties,Usage,Production
Description
Cholesteryl hemisuccinate is a cholesterol ester with anticancer activity. It inhibits the growth of murine C1498 myeloid and L1210 lymphocytic leukemia cells when used at concentrations of 50 and 150 μM, respectively. Cholesteryl hemisuccinate acts as an ionizable anionic detergent and is commonly used to stabilize unilamellar vesicles and liposomes. It has also been used as an emulsifying agent in various vesicular drug delivery systems for anticancer drugs, antibiotics, and oligonucleotides and to solubilize various proteins including chemokine receptor 1 as well as erythrocyte ghosts.
Uses
Cholesteryl Hemisuccinate is an oxidation product of polyunsaturated fatty acid of cholesterol that alters lysosome structure and functions and induces proinflammatory cytokine production in macrophages.
Definition
ChEBI: Cholesteryl hemisuccinate is a dicarboxylic acid monoester resulting from the formal condensation of the hydroxy group of cholesterol with one of the carboxy groups of succinic acid. A detergent that is often used to replace cholesterol in protein crystallography, biochemical studies of proteins, and pharmacology. It has a role as a detergent. It is a cholestane ester, a dicarboxylic acid monoester and a hemisuccinate. It is functionally related to a cholesterol.
General Description
Cholesteryl hemisuccinate (CHEMS) is an acidic cholesterol ester.
Biochem/physiol Actions
CHEMS can help to maintain the stability of dioleoylphosphatidylethanolamine (DOPE). This amphipathic lipid is used in mixtures with dioleoylphosphatidylethanolamine (DOPE) to form ′pH sensitive′ fusogenic vesicles. It can control cell growth.
Cholesteryl hemisuccinate Preparation Products And Raw materials
Raw materials
Preparation Products
Cholesteryl hemisuccinate Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23680
- Advantage
- 75
View Lastest Price from Cholesteryl hemisuccinate manufacturers
- Product
- CHEMS 1510-21-0
- Price
- US $0.00/g
- Min. Order
- 100g
- Purity
- >95.00%
- Supply Ability
- 100g
- Release date
- 2024-04-01
- Product
- Cholesteryl hemisuccinate 1510-21-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-09
- Product
- Cholesteryl hemisuccinate 1510-21-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11