Sulfo DBCO-PEG4-amine
- Product Name
- Sulfo DBCO-PEG4-amine
- CAS No.
- 2055198-05-3
- Chemical Name
- Sulfo DBCO-PEG4-amine
- Synonyms
- Sulfo DBCO-PEG4-NH2;12,15,18,21-Tetraoxa-4,8-diazatricosane-6-sulfonic acid, 23-amino-1-(11,12-dihydrodibenz[b,f]azocin-5(6H)-yl)-1,5,9-trioxo-
- CBNumber
- CB03363995
- Molecular Formula
- C32H42N4O10S
- Formula Weight
- 674.77
- MOL File
- 2055198-05-3.mol
Sulfo DBCO-PEG4-amine Property
- Density
- 1.36±0.1 g/cm3(Predicted)
- pka
- 0.34±0.50(Predicted)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-23310
- Product name
- SulfoDBCO-PEG4-amine
- Purity
- 95%
- Packaging
- 25mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- BP-23310
- Product name
- SulfoDBCO-PEG4-amine
- Purity
- 95%
- Packaging
- 100mg
- Price
- $495
- Updated
- 2021/12/16
- Product number
- RL-2421
- Product name
- DBCO-Sulfo-PEG(4)-NH2
- Packaging
- 100mg
- Price
- $810
- Updated
- 2021/12/16
- Product number
- RL-2421
- Product name
- DBCO-Sulfo-PEG(4)-NH2
- Packaging
- 500mg
- Price
- $2565
- Updated
- 2021/12/16
Sulfo DBCO-PEG4-amine Chemical Properties,Usage,Production
Description
Sulfo DBCO-PEG4-Amine is a water-soluble carboxyl-reactive building block with extended PEG spacer arm. In the presence of of activators (e.g. EDC, or HATU), this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. The hydrophilic sulfonated spacer arm greatly improves water solubility of DBCO derivatized molecules and a provides a long and flexible connection. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
Sulfo DBCO-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Sulfo DBCO-PEG4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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