CMP5
- Product Name
- CMP5
- CAS No.
- 1030021-40-9
- Chemical Name
- CMP5
- Synonyms
- CMP5;CMP-5 hydrochloride;CMP-5 hydrochloride (PRMT5-IN-5);CMP 5 hydrochloride,CMP5 hydrochloride
- CBNumber
- CB03364109
- Molecular Formula
- C21H22ClN3
- Formula Weight
- 351.88
- MOL File
- 1030021-40-9.mol
N-Bromosuccinimide Price
- Product number
- Axon2709
- Product name
- CMP5
- Purity
- 99%
- Packaging
- 10mg
- Price
- $104.5
- Updated
- 2021/12/16
CMP5 Chemical Properties,Usage,Production
Description
CMP5 is a potent and selective PRMT5 Inhibitor. CMP5 showed to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 μM. CMP-5 shows promise as a novel therapeutic_x000D_ approach for B-cell lymphomas.
Uses
CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected[1][2].
References
[1] Alinari L, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.Blood. 2015 Apr 16;125(16):2530-43. DOI:10.1182/blood-2014-12-619783
[2] Webb LM, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol.?2017?Feb 15;198(4):1439-1451. DOI:10.4049/jimmunol.1601702
CMP5 Preparation Products And Raw materials
Raw materials
Preparation Products
CMP5 Suppliers
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