tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate

Product Name: tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate
CAS No.: 929252-65-3
Chemical Name: tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate
Synonyms: 1-Piperidinecarboxylic acid,4-[[[4-(4-amino-2-fluorophenoxy)...;6-Methoxy-7-(N-BOC-4-piperidinemethoxy)-4-(2-fluoro-4-amino-phenoxy)-quinoline;6-Methoxy-7- (N-BOC-4 piperidimethoxy) -4- (2-fluoro-4-amino phenoxy) - quinoline;tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-[[[4-(4-amino-2-fluorophenoxy)-6-methoxy-7-quinolinyl]oxy]methyl]-, 1,1-dimethylethyl ester
CBNumber: CB03367685
Molecular Formula: C27H32FN3O5
Formula Weight: 497.56
MOL File: 929252-65-3.mol

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tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Property

Boiling point:: 619.7±55.0 °C(Predicted)
Density: 1.235±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 5.42±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 4056DP
Product name: Tert-butyl4-((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yloxy)methyl)piperidine-1-carboxylate
Packaging: 5g
Price: $181
Updated: 2021/12/16

Ambeed

Product number: A118348
Product name: tert-Butyl4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate
Purity: 97%
Packaging: 5g
Price: $137
Updated: 2021/12/16

Chemenu

Product number: CM227340
Product name: tert-Butyl4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate
Purity: 97%
Packaging: 1g
Price: $153
Updated: 2021/12/16

Alichem

Product number: 929252653
Product name: tert-Butyl4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate
Packaging: 1g
Price: $162
Updated: 2021/12/16

Chemenu

Product number: CM227340
Product name: tert-Butyl4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate
Purity: 97%
Packaging: 5g
Price: $421
Updated: 2021/12/16

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tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

849217-45-4

929252-65-3

Step 4. Synthesis of tert-butyl 4-(((4-(4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate (81): to a mixture of ethanol (8 mL) and water (4 mL) of Compound 80 (0.50 g, 0.95 mmol) was added iron powder (0.254 g, 4.55 mmol) and ammonium chloride ( 0.123 g, 2.26 mmol). The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, the reaction mixture was diluted with methanol and filtered to remove the solid suspension. The filtrate was concentrated and the resulting residue was purified by a Gilson automated purification system (eluent gradient: 35% to 57% methanol/dichloromethane) to afford the target product 4-(((4-(4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester 81 (0.25 g, 52% yield).

References

[1] Patent: US2008/4273, 2008, A1. Location in patent: Page/Page column 79; 80
[2] Patent: US2007/60613, 2007, A1. Location in patent: Page/Page column 17-18

tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Suppliers

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View Lastest Price from tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate manufacturers

Jinan Ande Pharmaceutical Co.,Ltd.

Product: tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate 929252-65-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100
Release date: 2022-02-24

929252-65-3, tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylateRelated Search:

1-Piperidinecarboxylic acid, 4-[[[4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-quinolinyl]oxy]methyl]-, 1,1-dimethylethyl ester

tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-[[[4-(4-amino-2-fluorophenoxy)-6-methoxy-7-quinolinyl]oxy]methyl]-, 1,1-dimethylethyl ester

1-Piperidinecarboxylic acid,4-[[[4-(4-amino-2-fluorophenoxy)...

6-Methoxy-7-(N-BOC-4-piperidinemethoxy)-4-(2-fluoro-4-amino-phenoxy)-quinoline

6-Methoxy-7- (N-BOC-4 piperidimethoxy) -4- (2-fluoro-4-amino phenoxy) - quinoline

929252-65-3