ChemicalBook > CAS DataBase List > 1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride

1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride

Product Name
1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride
CAS No.
1620278-72-9
Chemical Name
1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride
Synonyms
TLR7/8 agonist-5d;TLR7/8 agonist 1 2HCl;8 agonist 1 dihydrochloride;TLR7/8 Agonist 1 (hydrochloride);TLR7/8 Agonist 5d (hydrochloride);TLR7/8 agonist 1 (dihydrochloride);TLR7/8 agonist 1 dihydrochloride, 10 mM in DMSO;1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride;Toll-like Receptor (TLR),TLR7/8 agonist 1,TLR7/8 agonist 1 dihydrochloride,TLR-7/8 agonist 1 dihydrochloride,Inhibitor,inhibit
CBNumber
CB03374339
Molecular Formula
C22H26ClN5
Formula Weight
395.94
MOL File
1620278-72-9.mol
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1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMSO:83.33(Max Conc. mg/mL);192.72(Max Conc. mM)
form 
A solid
color 
Off-white to light yellow
InChI
InChI=1S/C22H25N5.ClH/c1-2-3-8-19-26-20-21(17-6-4-5-7-18(17)25-22(20)24)27(19)14-16-11-9-15(13-23)10-12-16;/h4-7,9-12H,2-3,8,13-14,23H2,1H3,(H2,24,25);1H
InChIKey
IIFIHBPSMOIXGG-UHFFFAOYSA-N
SMILES
C(C1C=CC(CN)=CC=1)N1C(=NC2C(N)=NC3=CC=CC=C3C1=2)CCCC.Cl
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28451
Product name
TLR7/8 Agonist 1 (hydrochloride)
Packaging
500μg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
28451
Product name
TLR7/8 Agonist 1 (hydrochloride)
Packaging
5mg
Price
$468
Updated
2024/03/01
Cayman Chemical
Product number
28451
Product name
TLR7/8 Agonist 1 (hydrochloride)
Packaging
1mg
Price
$131
Updated
2024/03/01
AK Scientific
Product number
3353EB
Product name
TLR7/8agonist1(dihydrochloride)
Packaging
1mg
Price
$243
Updated
2021/12/16
ChemScene
Product number
CS-0032947
Product name
TLR7/8agonist1(dihydrochloride)
Purity
98.47%
Packaging
10mg
Price
$550
Updated
2021/12/16
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1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride Chemical Properties,Usage,Production

Biological Activity

TLR7/8 agonist 1 dihydrochloride is a dual agonist of the toll-like receptor TLR7/TLR8.

in vitro

TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity.It retains TLR7- agonistic activity with an EC 50 of 20 nM. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens.

target

TLR7/TLR8

1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride Suppliers

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1620278-72-9, 1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochlorideRelated Search:


  • 1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride
  • TLR7/8 agonist 1 (dihydrochloride)
  • TLR7/8 agonist-5d
  • TLR7/8 Agonist 1 (hydrochloride)
  • 8 agonist 1 dihydrochloride
  • TLR7/8 Agonist 5d (hydrochloride)
  • Toll-like Receptor (TLR),TLR7/8 agonist 1,TLR7/8 agonist 1 dihydrochloride,TLR-7/8 agonist 1 dihydrochloride,Inhibitor,inhibit
  • TLR7/8 agonist 1 2HCl
  • TLR7/8 agonist 1 dihydrochloride, 10 mM in DMSO
  • 1620278-72-9