ChemicalBook > CAS DataBase List > 1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN

1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN

Product Name
1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN
CAS No.
183673-70-3
Chemical Name
1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN
Synonyms
1-t-Boc-piperidine-4-splro-5'-hydantoln;1-T-Boc-piperidine-4-spiro-5'-hydantoin;1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN;tert-Butyl-2,4-Dioxo-1,3,8-Triazaspiro[4.5;1-Tert-Boc-Piperidine-4-Spiro-5'-Hydantoin;8-Boc-2,4-dioxo-1,3,8-triazaspiro[4.5]decane;2,4-Dioxo-1,3,8-triazaspiro[4.5]decane, N8-BOC protected;8-tert-Butoxycarbonyl-1,3,8-triazaspiro[4.5]decane-2,4-dione;tert-Butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-carboxylate;tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate
CBNumber
CB0337964
Molecular Formula
C12H19N3O4
Formula Weight
269.3
MOL File
Mol file
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1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN Property

Melting point:
242-244°C
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Dichloromethane, DMSO, Methanol
form 
Solid
pka
10.10±0.20(Predicted)
color 
White to Off-White
InChI
InChI=1S/C12H19N3O4/c1-11(2,3)19-10(18)15-6-4-12(5-7-15)8(16)13-9(17)14-12/h4-7H2,1-3H3,(H2,13,14,16,17)
InChIKey
DHJXKTPWDXJQEK-UHFFFAOYSA-N
SMILES
N1C2(CCN(C(OC(C)(C)C)=O)CC2)C(=O)NC1=O
CAS DataBase Reference
183673-70-3
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
B663215
Product name
1-t-Boc-piperidine-4-spiro-5’-hydantoin
Packaging
2g
Price
$165
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18982
Product name
1-t-Boc-piperidine-4-spiro-5'-hydantoin
Packaging
2g
Price
$170
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18982
Product name
1-t-Boc-piperidine-4-spiro-5'-hydantoin
Packaging
250mg
Price
$50
Updated
2021/12/16
Synthonix
Product number
D6091
Product name
2,4-Dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylicacidtert-butylester
Purity
97%
Packaging
1g
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18982
Product name
1-t-Boc-piperidine-4-spiro-5'-hydantoin
Packaging
500mg
Price
$70
Updated
2021/12/16
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1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Uses

A cyclic a,a-disubstituted amino acid for preparation of water-soluble highly helical peptides

Uses

A cyclic α,α-disubstituted amino acid for preparation of water-soluble highly helical peptides.

Synthesis

151-50-8

506-87-6

79099-07-3

183673-70-3

An aqueous solution (50 mL) of potassium cyanide (22.5 g, 0.335 mol) was slowly added dropwise over a period of 5 minutes to a mixture of water (90 mL) and methanol (110 mL) containing N-tert-butoxycarbonyl-4-piperidone (32.48 g, 0.1598 mol) and ammonium carbonate (33.8 g, 0.351 mol). Upon completion of the dropwise addition, an off-white precipitate rapidly appeared in the reaction mixture. Subsequently, the reaction flask was sealed and the suspension was stirred continuously at room temperature for 72 hours. Upon completion of the reaction, the light yellow precipitate was collected by filtration and washed with a small amount of water to afford 8-Boc-2,4,8-triazaspiro[4.5]decane-1,3-dione (37.1 g, 86% yield) as a colorless solid.

References

[1] Patent: WO2009/64274, 2009, A1. Location in patent: Page/Page column 15
[2] Patent: WO2007/139813, 2007, A1. Location in patent: Page/Page column 17
[3] Patent: US2005/261322, 2005, A1. Location in patent: Page/Page column 19
[4] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 22, p. 2687 - 2692

1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN Preparation Products And Raw materials

Raw materials

Preparation Products

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1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN Suppliers

Canada 1 China 75 India 2 United Kingdom 2 United States 11 Global 91
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
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View Lastest Price from 1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN manufacturers

Career Henan Chemical Co
Product
1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN 183673-70-3
Price
US $2.00/KG
Min. Order
1KG
Purity
99%min
Supply Ability
300kg
Release date
2020-03-06

183673-70-3, 1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOINRelated Search:


  • 2,4-Dioxo-1,3,8-triazaspiro[4.5]decane, N8-BOC protected
  • tert-Butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate, 8-(tert-Butoxycarbonyl)-2,4-dioxo-1,3,8-triazaspiro[4.5]decane
  • 8-tert-Butoxycarbonyl-1,3,8-triazaspiro[4.5]decane-2,4-dione
  • 8-Boc-2,4-dioxo-1,3,8-triazaspiro[4.5]decane
  • 2,4-Dioxo-1,3-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester
  • 2,4-diketo-1,3,8-triazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester
  • 2,4-Dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylic Acid 1,1-DiMethylethyl Ester
  • 2,4-Dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester
  • 2,4-Dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester - D6091
  • tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate
  • 1,3,8-Triazaspiro[4.5]decane-8-carboxylic acid, 2,4-dioxo-, 1,1-diMethylethyl ester
  • tert-Butyl-2,4-Dioxo-1,3,8-Triazaspiro[4.5
  • 1-Tert-Boc-Piperidine-4-Spiro-5'-Hydantoin
  • Tert butyl 2,4-dioxo-1,3,8-triazaspiro [4.5] decane-8-carboxylic acid
  • 1,3,8-Triazaspiro[4.5]decane-8-carboxylic acid, 2,4-dioxo-,1...
  • 1,1-Dimethylethyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate
  • 1-t-Boc-piperidine-4-splro-5'-hydantoln
  • 1-T-Boc-piperidine-4-spiro-5'-hydantoin
  • 1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN
  • tert-Butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-carboxylate
  • 183673-70-3
  • Amino Acids & Derivatives
  • Hydantoins & Derivatives