ChemicalBook > CAS DataBase List > 1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol

1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol

Product Name
1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol
CAS No.
1394121-05-1
Chemical Name
1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol
Synonyms
181525;GNE-2861;GNE-2861; GNE 2861; GNE2861.;p21 activated kinases,inhibit,Inhibitor,PAK,GNE 2861,GNE-2861,GNE2861;1-[2-[3-(2-aminopyrimidin-4-yl)-2-(2-methoxyethylamino)benzimidazol-5-yl]ethynyl]cyclohexan-1-ol;1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol;1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol;Cyclohexanol, 1-[2-[1-(2-amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]-;1-((1-(2-Aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexan-1-ol
CBNumber
CB03380132
Molecular Formula
C22H26N6O2
Formula Weight
406.48
MOL File
1394121-05-1.mol
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1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol Property

storage temp. 
Store at -20°C
solubility 
DMSO:82.83(Max Conc. mg/mL);203.77(Max Conc. mM)
Ethanol:40.65(Max Conc. mg/mL);100.0(Max Conc. mM)
form 
A solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29458
Product name
GNE-2861
Packaging
5mg
Price
$303
Updated
2024/03/01
Tocris
Product number
6490
Product name
GNE2861
Purity
≥98%(HPLC)
Packaging
5
Price
$214
Updated
2021/12/16
ChemScene
Product number
CS-0012111
Product name
GNE2861
Purity
99.47%
Packaging
5mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0012111
Product name
GNE2861
Purity
99.47%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0012111
Product name
GNE2861
Purity
99.47%
Packaging
25mg
Price
$300
Updated
2021/12/16
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1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol Chemical Properties,Usage,Production

Biological Activity

GNE 2861 is a PAK inhibitor with selectivity for group II. It inhibits PAK4, PAK5 and PAK6 with IC50 values of 7.5, 36 and 126 nM, respectively.

in vitro

GNE-2861 is compound 4 from the reference.

target

IC50: 7.5 nM (PAK4), 36 nM (PAK5), 126 nM (PAK6)

storage

Store at -20°C

1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol Suppliers

China 23 United Kingdom 1 United States 5 Global 29
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1394121-05-1, 1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanolRelated Search:


  • 1-[2-[3-(2-aminopyrimidin-4-yl)-2-(2-methoxyethylamino)benzimidazol-5-yl]ethynyl]cyclohexan-1-ol
  • 1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol
  • GNE-2861; GNE 2861; GNE2861.
  • 1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol
  • 181525
  • GNE-2861
  • Cyclohexanol, 1-[2-[1-(2-amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]-
  • p21 activated kinases,inhibit,Inhibitor,PAK,GNE 2861,GNE-2861,GNE2861
  • 1-((1-(2-Aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexan-1-ol
  • 1394121-05-1
  • APIS