BRD4-IN-1 FL-411

Product Name: BRD4-IN-1 FL-411
CAS No.: 2118944-88-8
Chemical Name: BRD4-IN-1 FL-411
Synonyms: -411;FL-411;BRD4-IN-1;BRD4-IN-1 FL-411;FL-411;FL 411;FL411;FL-411, 10 mM in DMSO;Inhibitor,inhibit,FL-411,Epigenetic Reader Domain;2-(4-Hydroxy-3,5-dimethylphenyl)-7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(1H)-one;Pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(1H)-one, 5,6,7,8-tetrahydro-2-(4-hydroxy-3,5-dimethylphenyl)-7-methyl-
CBNumber: CB03381023
Molecular Formula: C18H19N3O2S
Formula Weight: 341.43
MOL File: 2118944-88-8.mol

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BRD4-IN-1 FL-411 Property

Boiling point:: 577.5±60.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:5.4(Max Conc. mg/mL);15.82(Max Conc. mM)
form: Solid
pka: 8.97±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F532265
Product name: FL411
Packaging: 2.5mg
Price: $605
Updated: 2021/12/16

ChemScene

Product number: CS-0034229
Product name: FL-411
Purity: 98.02%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0034229
Product name: FL-411
Purity: 98.02%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0034229
Product name: FL-411
Purity: 98.02%
Packaging: 25mg
Price: $1100
Updated: 2021/12/16

ChemScene

Product number: CS-0034229
Product name: FL-411
Purity: 98.02%
Packaging: 50mg
Price: $1750
Updated: 2021/12/16

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BRD4-IN-1 FL-411 Chemical Properties,Usage,Production

Uses

FL 411, is a potent and selective BRD4 inhibitor.

in vivo

To evaluate the antitumor activity of FL-411 in vivo, two breast tumor xenograft models, namely, MCF-7 and MDA-MB-231 cell lines models, are used. The in vivo study is conducted using three different doses of FL-411: 25 mg/kg, 50 mg/kg, and 100 mg/kg. In all the models, FL-411 shows significant tumor growth inhibition in a dose-dependent manner as determined by 80% and 76% tumor growth inhibition ratio in MCF-7 and MDA-MB-231 cell models, respectively. A remarkable loss of tumor weights is observed in all dose groups (p<0.001). FL-411 displays no obvious effects on the body weight of all the treatment groups. To examine whether FL-411-mediated inhibition of tumor growth in vivo is associated with reduced cell proliferation and the increased autophagy-associated cell death, tumor tissues from control and FL-411-treated mice are processed for the immunohistochemical analysis of Ki-67 and LC3. FL-411 treatment obviously reduces the number of Ki-67 (p<0.001) positive cells as well as increases autophagy levels, which is determined by increased LC3 expression (p<0.001)^[1].

IC 50

BRD4(1): 0.43 μM (IC₅₀)

BRD4-IN-1 FL-411 Preparation Products And Raw materials

Raw materials

Preparation Products

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BRD4-IN-1 FL-411 Suppliers

China 60 India 1 United States 4 Global 65

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9675
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 9955
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
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Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
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Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-037163312495,13303845143 13303845143
Fax: QQ3001379618
Email: 3001379618@qq.com
Country: China
ProdList: 10197
Advantage: 58

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View Lastest Price from BRD4-IN-1 FL-411 manufacturers

Career Henan Chemical Co

Product: BRD4-IN-1 FL-411 2118944-88-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

2118944-88-8, BRD4-IN-1 FL-411Related Search:

BRD4-IN-1 FL-411

FL-411

FL-411;FL 411;FL411

BRD4-IN-1

Pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(1H)-one, 5,6,7,8-tetrahydro-2-(4-hydroxy-3,5-dimethylphenyl)-7-methyl-

-411

2-(4-Hydroxy-3,5-dimethylphenyl)-7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(1H)-one

Inhibitor,inhibit,FL-411,Epigenetic Reader Domain

FL-411, 10 mM in DMSO

2118944-88-8