K-756
- Product Name
- K-756
- CAS No.
- 130017-40-2
- Chemical Name
- K-756
- Synonyms
- K-756;K-756 >=98% (HPLC);K-756, 10 mM in DMSO;K-756,PARP,Inhibitor,poly ADP ribose polymerase,K756,K 756,inhibit;3-((1-(6,7-Dimethoxyquinazolin-4-yl)piperidin-4-yl)methyl)-3,4-dihydroquinazolin-2(1H)-one;2(1H)-Quinazolinone, 3-[[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]methyl]-3,4-dihydro-
- CBNumber
- CB03384776
- Molecular Formula
- C24H27N5O3
- Formula Weight
- 433.5
- MOL File
- 130017-40-2.mol
K-756 Property
- Melting point:
- 216-218 °C
- Boiling point:
- 680.0±55.0 °C(Predicted)
- Density
- 1.261±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:4.55(Max Conc. mg/mL);10.5(Max Conc. mM)
- pka
- 14.92±0.20(Predicted)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0035125
- Product name
- K-756
- Purity
- >99.0%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-0035125
- Product name
- K-756
- Purity
- >99.0%
- Packaging
- 10mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- CS-0035125
- Product name
- K-756
- Purity
- >99.0%
- Packaging
- 25mg
- Price
- $680
- Updated
- 2021/12/16
K-756 Chemical Properties,Usage,Production
Description
K-756 is a a selective Wnt/β-catenin pathway inhibitor. K-756 is also a tankyrase (TNKS) inhibitor. K-756 binds to the induced pocket of TNKS and inhibits its enzyme activity. could be a leading compound in the development of anticancer agents.
in vitro
K-756 binds to the induced pocket of TNKS and inhibits its enzyme activity. Moreover, PARP family enzyme assays showed that K-756 is a selective TNKS inhibitor. K-756 inhibited the cell growth of APC-mutant colorectal cancer COLO 320DM and SW403 cells by inhibiting the Wnt/β-catenin pathway. _x000D_ _x000D_ Reference: Mol Cancer Ther. 2016 Jul;15(7):1525-34. https://pubmed.ncbi.nlm.nih.gov/27196752/
in vivo
An in vivo study showed that the oral administration of K-756 inhibited the Wnt/β-catenin pathway in colon cancer xenografts in mice._x000D_ _x000D_ Reference: Mol Cancer Ther. 2016 Jul;15(7):1525-34. https://pubmed.ncbi.nlm.nih.gov/27196752/
target
K-756 is a direct and selective tankyrase (TNKS) inhibitor, which inhibits the ADP-ribosylation activity of TMS1 amd TMLS2 with IC50s of 31 and 36 nM, respectively.
K-756 Preparation Products And Raw materials
Raw materials
Preparation Products
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