(4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- Product Name
- (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- CAS No.
- 639091-78-4
- Chemical Name
- (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- Synonyms
- RARECHEM AL BW 2482;2-(Boc-amino)-4-(aminomethyl)pyridine;tert-butyl N-[4-(aMinoMethyl)pyridin-2-yl]carbaMate;(4-Aminomethyl-pyridin-2-yl)-carbamic acid tert-butyl;(4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER;Carbamic acid, N-[4-(aminomethyl)-2-pyridinyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB0339201
- Molecular Formula
- C11H17N3O2
- Formula Weight
- 223.27
- MOL File
- 639091-78-4.mol
(4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER Property
- Melting point:
- 131-132 °C
- Boiling point:
- 321.9±32.0 °C(Predicted)
- Density
- 1.164±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 12.42±0.70(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- 072915
- Product name
- (4-Aminomethylpyridin-2-yl)carbamic acidtert-butyl ester
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $278
- Updated
- 2021/12/16
- Product number
- FA153565
- Product name
- (4-Aminomethylpyridin-2-yl)carbamic acid tert-butyl ester
- Packaging
- 1g
- Price
- $289
- Updated
- 2021/12/16
- Product number
- CHM0299962
- Product name
- 2-(BOC-AMINO)-4-(AMINOMETHYL)PYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.44
- Updated
- 2021/12/16
- Product number
- 072915
- Product name
- (4-Aminomethylpyridin-2-yl)carbamic acidtert-butyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $599
- Updated
- 2021/12/16
- Product number
- FA153565
- Product name
- (4-Aminomethylpyridin-2-yl)carbamic acid tert-butyl ester
- Packaging
- 5G
- Price
- $982
- Updated
- 2021/12/16
(4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Synthesis
856897-86-4
639091-78-4
The general procedure for the synthesis of 2-(BOC-amino)-4-(aminomethyl)pyridine from the compound (CAS: 856897-86-4) is as follows:(b) Preparation of tert-butyl (4-aminomethylpiperidin-2-yl)carbamate; a solution of sodium borohydride (0.92 g, 24 mmol) in water (25 mL) was added to a Pd/C slurry (10%, 50% wet weight) , water (25 mL) was added with stirring, followed by rapid dropwise addition of a solution of tert-butyl (4-azidomethylpyridin-2-yl)carbamate (0.40 g, 6.1 mmol; see step (a) above) in THF (75 mL), and the reaction was carried out under cooling in an ice bath. The reaction mixture was stirred at room temperature for 4 h, followed by the slow addition of aqueous sodium bisulfate to an acidic pH. The reaction mixture was filtered by pumping through a Celite pad and washed with water. The combined aqueous layers were washed with ethyl acetate, adjusted to an alkaline pH by addition of aqueous NaOH and extracted with ethyl acetate (3×). The combined organic phases were washed with water, dried (Na2SO4), filtered and the solvent evaporated under reduced pressure. The crude product (1.1 g, 85% yield) was crystallized and used without further purification.1H NMR (300 MHz, CDCl3) δ 10.06 (m, 1H), 8.55 (m, 1H), 7.94 (m, 1H), 6.88 (m, 1H), 3.83 (bs, 2H), 1.50 (s, 9H).
References
[1] Patent: WO2005/75424, 2005, A1. Location in patent: Page/Page column 108
[2] Patent: WO2005/58826, 2005, A1. Location in patent: Page/Page column 99-100
(4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
(4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers
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- Country
- United Kingdom
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