ChemicalBook > CAS DataBase List > N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide

N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide

Product Name
N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CAS No.
1798310-55-0
Chemical Name
N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
Synonyms
AR420626;AR420626, 10 mM in DMSO;AR420626,Inhibitor,inhibit;N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide;3-Quinolinecarboxamide, N-(2,5-dichlorophenyl)-4-(2-furanyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-;N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CBNumber
CB03544752
Molecular Formula
C21H18Cl2N2O3
Formula Weight
417.29
MOL File
1798310-55-0.mol
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N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide Property

Boiling point:
619.3±55.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 2 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml
form 
A crystalline solid
pka
12.30±0.70(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17531
Product name
AR420626
Purity
≥95%
Packaging
500μg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17531
Product name
AR420626
Purity
≥95%
Packaging
1mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
17531
Product name
AR420626
Purity
≥95%
Packaging
5mg
Price
$299
Updated
2024/03/01
Cayman Chemical
Product number
17531
Product name
AR420626
Purity
≥95%
Packaging
10mg
Price
$426
Updated
2024/03/01
Tocris
Product number
6163
Product name
AR420626
Purity
≥98%(HPLC)
Packaging
25
Price
$314
Updated
2021/12/16
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N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide Chemical Properties,Usage,Production

Uses

AR 420626 is a selective and moderately potent positive allosteric modular (PAM)-agonist of the FFA3 receptor, which inhibits short chain fatty acids in a noncompetitive manner as a negative allosteric modulator in human and rodent cells.

Biological Activity

AR420626 is a selective agonist of Free Fatty Acid 3 receptor FFA3 (previously called GPR41). FFA3 is expressed in adipose tissue, gut, and the peripheral nervous system and normally activated by short chain fatty acids (SCFAs) produced in the body through the fermentation of complex carbohydrates by the gut microbiota. There is increasing interest in the role of the various free fatty acid receptors and SCFAs as chemical messengers in energy regulation and regulation of inflammatory processes and as therapeutic targets in the treatment of various metabolic and inflammatory conditions. AR420626 has an EC50 value of 117 nM for FFAR3 and did not activate FFAR2 in concentrations up to 100 μM.

storage

Store at -20°C

N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide Suppliers

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1798310-55-0, N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamideRelated Search:


  • N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
  • N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
  • AR420626
  • AR420626,Inhibitor,inhibit
  • 3-Quinolinecarboxamide, N-(2,5-dichlorophenyl)-4-(2-furanyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-
  • AR420626, 10 mM in DMSO
  • 1798310-55-0