Labeled d8 Desmethyl Clozapine Hydrochloride

Product Name: Labeled d8 Desmethyl Clozapine Hydrochloride
CAS No.: 1189888-77-4
Chemical Name: Labeled d8 Desmethyl Clozapine Hydrochloride
Synonyms: [2H8]-N-Desmethyl Clozapine;Labeled d8 Desmethyl Clozapine Hydrochloride;N-DESMETHYLCLOZAPINE (D8, 98%) 100 UG/ML IN METHANOL;6-chloro-10-[(2,2,3,3,5,5,6,6-2H?)piperazin-1-yl]-2,9-diazatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
CBNumber: CB03567643
Molecular Formula: C17H17ClN4
Formula Weight: 312.8
MOL File: 1189888-77-4.mol

More

Less

Labeled d8 Desmethyl Clozapine Hydrochloride Property

storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml
form: A solid
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 26027
Product name: N-Desmethylclozapine-d8
Packaging: 500μg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 26027
Product name: N-Desmethylclozapine-d8
Packaging: 1mg
Price: $171
Updated: 2024/03/01

TRC

Product number: D292002
Product name: N-DesmethylClozapine-d8
Packaging: 1mg
Price: $175
Updated: 2021/12/16

TRC

Product number: D292002
Product name: N-DesmethylClozapine-d8
Packaging: 10mg
Price: $1355
Updated: 2021/12/16

AK Scientific

Product number: 6414EM
Product name: N-DesmethylClozapine-d8
Packaging: 1mg
Price: $287
Updated: 2021/12/16

More

Less

Labeled d8 Desmethyl Clozapine Hydrochloride Chemical Properties,Usage,Production

Uses

A major labelled metabolite of clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.

Biological Activity

N-Desmethylclozapine-d8 is intended for use as an internal standard for the quantification of N-desmethylclozapine by GC- or LC-MS. N-Desmethylclozapine is an active metabolite of the atypical antipsychotic clozapine .1 It was originally described as an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50 = 7.1 nM in rat choroid plexus) and later as an inverse agonist using human recombinant receptors.2,3 N-Desmethylclozapine is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors.3,1,4 N-Desmethylclozapine (30 mg/kg) decreases exploratory locomotor activity and increases prepulse inhibiton of the acoustic startle response in mice.5

References

1.Burstein, E.S., Ma, J., Wong, S., et al.Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: Identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonistJ. Pharmacol. Exp. Ther.315(3)1278-1287(2005) 2.Kuoppam?ki, M., Syv?lahti, E., and Hietala, J.Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonistsEur. J. Pharmacol.245(2)179-182(1993) 3.Lameh, J., Burstein, E.S., Taylor, E., et al.Pharmacology of N-desmethylclozapinePharmacol. Ther.115(2)223-231(2007) 4.Odagaki, Y., Kinoshita, M., and Ota, T.Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranesJ. Psychopharmacol.30(9)896-912(2016) 5.Maehara, S., Hikichi, H., and Ohta, H.Behavioral effects of N-desmethylclozapine on locomotor activity and sensorimotor gating function in mice-Possible involvement of muscarinic receptorsBrain Res.1418111-119(2011)

Labeled d8 Desmethyl Clozapine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Labeled d8 Desmethyl Clozapine Hydrochloride Suppliers

China 15 India 2 United States 4 Global 21

Artis Biotech Co. Ltd.

Tel: 0575-18780151478 18582380095
Fax: 0575-89298961
Email: sales@artisbio.com
Country: China
ProdList: 2964
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Chengdu Novel Biomedical Co., Ltd.

Tel: 028-85255396 18302801538
Fax: 028-85255396
Email: cdnovell@163.com
Country: China
ProdList: 2310
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44808
Advantage: 58

Manhag Testing Technology Co., Ltd

Tel: 020-020-3846236 17688849268
Email: 2443244976@qq.com
Country: China
ProdList: 7775
Advantage: 58

PureChemland Co.,Ltd.

Tel: 18581895003 18084815636
Email: 3848291069@qq.com
Country: China
ProdList: 3594
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 15583
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9267
Advantage: 58

Henan Vcommend Consultrading Co., Ltd.

Tel: 13393721940
Email: sales@vcommend.com
Country: China
ProdList: 9962
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 17301488900
Fax: 025-85560043
Email: judy.xia@synzest.com
Country: China
ProdList: 12582
Advantage: 58

Xi'an Ruipuyuan Biotechnology Co., Ltd

Tel: 029-18909235869 18909235890
Email: customsynthesis@rpybiotech.com
Country: China
ProdList: 712
Advantage: 58

SHANGHAI ZZBIO CO., LTD.

Tel: 15102117276 19921389125
Email: tech@zzbioco.com
Country: China
ProdList: 12065
Advantage: 58

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 70071
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

1189888-77-4, Labeled d8 Desmethyl Clozapine HydrochlorideRelated Search:

N-Desmethyl Loperamide-d3 N-Desmethyl Droloxifene-d5 N-Desmethyl Pirenzepine-d8

Labeled d8 Desmethyl Clozapine Hydrochloride

N-DESMETHYLCLOZAPINE (D8, 98%) 100 UG/ML IN METHANOL

[2H8]-N-Desmethyl Clozapine

6-chloro-10-[(2,2,3,3,5,5,6,6-2H?)piperazin-1-yl]-2,9-diazatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,9,12,14-heptaene

1189888-77-4