2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE

Product Name: 2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE
CAS No.: 1563-56-0
Chemical Name: 2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE
Synonyms: C2HyBnN2O;Bromazepam Impurity A;Tocopherol Impurity 30;Bromazepam EP Impurity A;2-(2-AMINO-5-BROMOBENZOYL);2-amino-5-bromobenzoylpyridine;2-(2-Ao-5-bromobenzoyl) pyridine;2-(5-Bromo-2-aminobenzoyl)pyridine;2-(2-AMino-5-BroMobenzoyl) Pyridin;2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE
CBNumber: CB0371601
Molecular Formula: C12H9BrN2O
Formula Weight: 277.12
MOL File: 1563-56-0.mol

More

Less

2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE Property

Melting point:: 98-100℃
Boiling point:: 451℃
Density: 1.546
Flash point:: 227℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Sparingly)
form: Solid
pka: 2.66±0.10(Predicted)
color: Light Yellow to Yellow
InChI: InChI=1S/C12H9BrN2O/c13-8-4-5-10(14)9(7-8)12(16)11-3-1-2-6-15-11/h1-7H,14H2
InChIKey: KHVZPFKJBLTYCC-UHFFFAOYSA-N
SMILES: C(C1=CC(Br)=CC=C1N)(C1=NC=CC=C1)=O

More

Less

Safety

HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: A601785
Product name: 2-(2-Amino-5-bromobenzoyl)pyridine
Packaging: 50mg
Price: $65
Updated: 2021/12/16

TRC

Product number: A601785
Product name: 2-(2-Amino-5-bromobenzoyl)pyridine
Packaging: 250mg
Price: $275
Updated: 2021/12/16

TRC

Product number: A601785
Product name: 2-(2-Amino-5-bromobenzoyl)pyridine
Packaging: 1g
Price: $545
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IA17613
Product name: 2-(2-Amino-5-bromobenzoyl)pyridine
Packaging: 2mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IA17613
Product name: 2-(2-Amino-5-bromobenzoyl)pyridine
Packaging: 50mg
Price: $520
Updated: 2021/12/16

More

Less

2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

2-(2-Amino-5-bromobenzoyl)pyridine is used as an intermediate in the preparation of Bromazepam.

Biological Activity

2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE (2ABBP) has been shown to have anti-inflammatory properties in rat liver microsomes and cell culture experiments. The mechanism of action may involve inhibition of cyclooxygenase enzymes, which are involved in prostaglandin synthesis. 2ABBP also binds to human serum albumin and chaperones, proteins that bind other proteins or small molecules.

Synthesis

109-04-6

5794-88-7

1563-56-0

General procedure for the synthesis of 2-(2-amino-5-bromo-benzoyl)pyridine from 2-bromopyridine and 2-amino-5-bromobenzoic acid: 2-bromopyridine (173.93 g, 1101 mmol, 4.4 eq.) was slowly added to a mixture of 2.5 M n-butyllithium hexane solution (400 mL, 1000 mmol, 4 eq.) and ethyl ether (1 L) at -40 °C. 4.4 eq.). The reaction mixture was stirred at -40 °C for 1 h. A solution of 2-amino-5-bromobenzoic acid (54.14 g, 250.6 mmol, 1 eq.) in tetrahydrofuran (THF, 1 L) was added dropwise. The reaction system was slowly warmed to 0 °C and stirring was continued at this temperature for 2 hours. Subsequently, chlorotrimethylsilane (625 mL, 4924 mmol, 20 eq.) was added to quench the reaction. The mixture was stirred at room temperature for 30 minutes, then cooled to 0 °C and quenched with 3N hydrochloric acid (625 mL). The aqueous layer was separated and the organic layer was extracted once with 3N hydrochloric acid. The combined aqueous phases were neutralized with solid sodium hydroxide pellets while cooling in an ice bath. The neutralized aqueous phase was extracted with ether (3 x 1L). The combined ether extracts were dried with anhydrous sodium sulfate, filtered and concentrated to give a black oil. The crude product was purified by fast chromatography (silica gel column, 1 L, eluent 20-30% ethyl acetate/hexane) to afford the target compound 2-(2-amino-5-bromo-benzoyl)pyridine as a brown solid (62 g, 224 mmol, 89.3% yield).

References

[1] Patent: EP1183243, 2006, B1. Location in patent: Page/Page column 11
[2] Patent: WO2014/154762, 2014, A1. Location in patent: Page/Page column 62
[3] Patent: US2014/296230, 2014, A1. Location in patent: Paragraph 0303-0306
[4] Patent: CN108264499, 2018, A. Location in patent: Paragraph 0050-0051; 0075; 0076; 0077-0079

2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE Suppliers

Canada 1 China 192 Germany 1 India 8 Ukraine 1 United Kingdom 1 United States 9 Global 213

YICHANG TIANRUI BIOPHARM CO., LTD

Tel: 13469840438
Email: caiweiguo@renfu.com.cn
Country: China
ProdList: 49
Advantage: 58

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

Viwit Pharmaceutical Co., Ltd.

Tel: 0632-0632-2980981 15063270987
Fax: 0632-2989678
Email: service.china3@viwit.com
Country: China
ProdList: 137
Advantage: 55

Shouguang Xinghai Chemical Co. LTD

Tel: 15666881566
Email: 449211804@qq.com
Country: China
ProdList: 46
Advantage: 58

Shanghai Shanyuan pharmaceutical technology co., LTD

Tel: 021-31761238 13167072949
Fax: 021-31761238
Email: 3146446224@qq.com
Country: China
ProdList: 1379
Advantage: 55

Jiangsu Jingye Pharmaceutical

Tel: 0519-82765788 18001496617
Email: 2807841045@qq.com
Country: China
ProdList: 108
Advantage: 58

Shanghai Yatan Pharmaceutical Research and Development Co. LTD

Tel: 021-58003085 18817202306
Fax: QQ1060196522
Email: quhs@neutanpharma.com
Country: China
ProdList: 182
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2809
Advantage: 65

More

Less

View Lastest Price from 2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE manufacturers

Shandong Vital Biotechnology Co., Ltd.

Product: 2-(2-Amino-5-bromobenzoyl)pyridine 1563-56-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100tons
Release date: 2025-11-19

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-(2-Amino-5-bromobenzoyl)pyridine 1563-56-0
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Xi'an Yutbon Pharmaceutical Technology Co., Ltd

Product: 2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE 1563-56-0
Price: US $480.00/kg
Min. Order: 1kg
Purity: 98 %
Supply Ability: 8Ton
Release date: 2024-05-15

1563-56-0, 2-(2-AMINO-5-BROMOBENZOYL) PYRIDINERelated Search:

2-bromo-N-[4-bromo-2-(pyridin-2-ylcarbonyl)phenyl]acetamide 3-AMino-6-broMo-4-(pyridin-2-yl)quinolin-2(1H)-one Bromazepam Impurity 3 Bromazepam Impurity 2 2-Chloromethyl-3,4-dimethoxypyridinium chloride 2-Chloromethyl-3-methyl-4-(3-methoxypropoxy)pyridine hydrochloride N-[4-Bromo-2-(2-pyridylcarbonyl)phenyl]-2-chloroacetamide 2-(2-Aminobenzoyl)pyridine 2-(3-BROMOBENZOYL)PYRIDINE 2-(2-amino-5-bromobenzoyl)pyridine (intermediate of bromazepam) 2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE 2-(2-BENZAMIDO-5-BROMOBENZOYL)PYRIDINE

Bromazepam EP Impurity A

4-bromo-2-[(pyridin-2-yl)carbonyl]aniline

2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE

(2-amino-5-bromophenyl)-pyridin-2-ylmethanone

(2-azanyl-5-bromo-phenyl)-pyridin-2-yl-methanone

(2-Amino-5-bromophenyl)(2-pyridinyl)methanone

Methanone, (2-amino-5-bromophenyl)-2-pyridinyl-

Pyridine, 2-(2-amino-5-bromobenzoyl)

2-amino-5-bromobenzoylpyridine

2-(2-Amino-5-Bromobenzoyl) Pyridine 1-(2,4-Dichlorophenyl)ethanone

2-AMino-5-broMophenyl 2-pyridyl Ketone

2-(5-Bromo-2-aminobenzoyl)pyridine

2-(2-AMino-5-BroMobenzoyl) Pyridin

Bromazepam Impurity A

2-(2-Ao-5-bromobenzoyl) pyridine

2-(2-Pyridylcarbonyl)-4-bromobenzeneamine

4-Bromo-2-[(2-pyridyl)carbonyl]aniline

2-(Pyridin-2-Yl-Carbonyl)-4-Bromoaniline

2-(2-AMINO-5-BROMOBENZOYL)

C2HyBnN2O

Tocopherol Impurity 30

1563-56-0

C12H9BrN2O

C152H9BrN2O

(intermediate of bromazepam)

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals