Z-PHE-PHE-FLUOROMETHYLKETONE
- Product Name
- Z-PHE-PHE-FLUOROMETHYLKETONE
- CAS No.
- 108005-94-3
- Chemical Name
- Z-PHE-PHE-FLUOROMETHYLKETONE
- Synonyms
- Z-FF-FMK;Z-PHE-PHE-FMK;Cathepsin L-IN-2;(Rac)-Z-Phe-Phe-FMK;Z-PHE-PHE-FLUOROMETHYLKETONE;Carbamic acid, [2-[[3-fluoro-2-oxo-1-(phenylmethyl)propyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester (9CI)
- CBNumber
- CB0373973
- Molecular Formula
- C27H27FN2O4
- Formula Weight
- 462.51
- MOL File
- Mol file
Z-PHE-PHE-FLUOROMETHYLKETONE Property
- Boiling point:
- 707.5±60.0 °C(Predicted)
- Density
- 1.214±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 20mM
- form
- solid
- pka
- 11.07±0.46(Predicted)
- color
- White to off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 219421
- Product name
- CathepsinLInhibitorI-CAS108005-94-3-Calbiochem
- Purity
- TheCathepsinLInhibitorI,alsoreferencedunderCAS108005-94-3,controlsthe
- Packaging
- 1mg
- Price
- $164
- Updated
- 2025/07/31
- Product number
- HCH0066896
- Product name
- Z-PHE-PHE-FLUOROMETHYL KETONE
- Purity
- 95.00%
- Packaging
- 3MG
- Price
- $917.07
- Updated
- 2021/12/16
Z-PHE-PHE-FLUOROMETHYLKETONE Chemical Properties,Usage,Production
Uses
Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L/B inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
Biological Activity
Cell permeable: yes', 'Primary Target
cathepsin L', 'Product does not compete with ATP.', 'Reversible: no
IC 50
Cathepsin B; cathepsin L
References
[1] Jonathan Frew, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 Mar 16;15(1):21. DOI:10.1186/s13024-020-00369-5
Z-PHE-PHE-FLUOROMETHYLKETONE Preparation Products And Raw materials
Raw materials
Preparation Products
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