4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID
- Product Name
- 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID
- CAS No.
- 53473-36-2
- Chemical Name
- 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID
- Synonyms
- Cinacalcet-29;Sinacase Impurity 53.;Cinacalcet Impurity 42;P-Trifluoromethyl benzylacetic acid;4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID;P-trifluoromethyl phenylpropionic acid;4-(TRIFLUOROMETHYL)PHENYLPROPIONIC ACID;3-(4-TrifluroMethylphenyl)propanoic acid;4-(TrifluoroMethyl)-benzenepropanoic acid;4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID 95%
- CBNumber
- CB0376626
- Molecular Formula
- C10H9F3O2
- Formula Weight
- 218.17
- MOL File
- 53473-36-2.mol
4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID Property
- Melting point:
- 106-110 °C(lit.)
- Boiling point:
- 0°C
- Density
- 1.307±0.06 g/cm3(Predicted)
- Flash point:
- 0°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 4.54±0.10(Predicted)
- form
- Crystalline Powder or Solid
- color
- White to light brown
- InChI
- InChI=1S/C10H9F3O2/c11-10(12,13)8-4-1-7(2-5-8)3-6-9(14)15/h1-2,4-5H,3,6H2,(H,14,15)
- InChIKey
- OEIUMLSCWINLBB-UHFFFAOYSA-N
- SMILES
- C1(CCC(O)=O)=CC=C(C(F)(F)F)C=C1
- CAS DataBase Reference
- 53473-36-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 457035
- Product name
- 4-(Trifluoromethyl)hydrocinnamic acid
- Purity
- 95%
- Packaging
- 10g
- Price
- $332
- Updated
- 2023/06/20
- Product number
- 457035
- Product name
- 4-(Trifluoromethyl)hydrocinnamic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $42.2
- Updated
- 2023/01/07
- Product number
- T2927
- Product name
- 3-[4-(Trifluoromethyl)phenyl]propionic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- T2927
- Product name
- 3-[4-(Trifluoromethyl)phenyl]propionic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $128
- Updated
- 2025/07/31
- Product number
- T796565
- Product name
- 4-(Trifluoromethyl)hydrocinnamic acid
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID Chemical Properties,Usage,Production
Chemical Properties
White to pale yellow crystalline powder
Uses
4-(Trifluoromethyl)hydrocinnamic Acid acts as a reagent in the synthesis of (poly)fluorinated neprilysin inhibitor. It is also applied in pesticides, medicines, dyes and in functional materials preparation because of it’s excellent bioactive properties.
Synthesis
16642-92-5
53473-36-2
GENERAL STEPS: (E)-4-Trifluoromethylcinnamic acid (10.0 g, 46.3 mmol) was mixed with 10 wt% Pd/C catalyst (250 mg) in ethanol (100 mL). The reaction mixture was placed under hydrogen atmosphere (6 bar) and the reaction was stirred at room temperature for 21 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to remove the solvent to afford 3-(4-trifluoromethyl)phenylpropionic acid as a white solid (10.1 g, 46.1 mmol, 100% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ 2.73 (t, J = 7.6 Hz, 2H), 3.03 (t, J = 7.6 Hz, 2H), 7.33 (d, J = 8.0 Hz, 2H), 7.56 (d, J = 8.1 Hz, 2H).
References
[1] Patent: WO2010/64212, 2010, A1. Location in patent: Page/Page column 23
[2] Canadian Journal of Chemistry, 2012, vol. 90, # 9, p. 758 - 761
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 10, p. 3557 - 3567
[4] Patent: US2010/10226, 2010, A1. Location in patent: Page/Page column 7-8
[5] Patent: US2010/305325, 2010, A1. Location in patent: Page/Page column 2; 3; 8
4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID Suppliers
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View Lastest Price from 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID manufacturers
- Product
- 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID 53473-36-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-29
- Product
- 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID 53473-36-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID 53473-36-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-11