THENIUM CLOSYLATE Property

Melting point:

159-160°C

storage temp. 

-20°C Freezer

solubility 

Acetonitrile (Slightly), Methanol, Water (Slightly)

form 

Solid

color 

White to Off-White

CAS DataBase Reference

4304-40-9

Hazard and Precautionary Statements (GHS)

THENIUM CLOSYLATE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Thenium closylate,ZYF Pharm Chemical

Uses

Active against parasitic nematodes, especially those of the stomach and intestines.

Manufacturing Process

2-Chlormethylthiophene (6.6 g) was added to a solution of 1-dimethylamino- 2-phenoxyethane (8.2 g) in acetone (45 ml). On standing for 30 min an oil separeted. The resulting suspension was heated to reflux for a further 30 min and cooled. On standing, the separated oil partially crystallized. The supernatant liquors were decanted and the residue was recrystallized by dissolution in warm isopropanol and careful precipitation with ethyl acetate or ether to give colourless needles N,N-dimethyl-N-2-phenoxyethyl-N-2'- thenylammonium chloride monohydrate, M.P. 85-86°C.
A solution of free base of the last compound and p-chlorobenzenesulfonic acid (molar ratio 1:1) were reacted together in boiling acetone. After 30 min the solution was cooled and ethyl acetate added to precipitate a colourless solid of N,N-dimethyl-N-(2-phenoxyethyl)-N-(2-thenyl)ammonium 4- chlorbenzolsulfonate.

Therapeutic Function

Anthelmintic