3,3'-IMINODIPROPIONITRILE Property

Melting point:

-6 °C

Boiling point:

205 °C25 mm Hg(lit.)

Density 

1.02 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.47(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

pka

6.13±0.19(Predicted)

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Water Solubility 

Soluble in water.

Stability:

Stable, but moisture sensitive. Reaction with moisture may lead to a build up of pressure in sealed bottles. Combustible. Incompatible with strong oxidizing agents.

CAS DataBase Reference

111-94-4(CAS DataBase Reference)

EPA Substance Registry System

3,3'-Iminobispropanenitrile (111-94-4)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

RIDADR 

UN 3334

WGK Germany 

2

RTECS 

UG2975000

TSCA 

Yes

HS Code 

29269095

Hazardous Substances Data

111-94-4(Hazardous Substances Data)

Toxicity

A neurotoxic synthetic nitrile that causes proximal axonopathies in the spinal cord and brain stem. The proximal axonal swellings are due to interruption of slow axonal transport, resulting in a large accumulation of neurofilaments. Secondary to these effects is a progressive atrophy of the distal axon, secondary demyelination, and gliosis. The slow axonal transport defect appears to be selective, as little evidence for perturbations in fast axonal transport have been reported. Behaviorally, IDPN induces hyperactivity, a “waltzing syndrome,” circling and head-rolling in mice and rats. IDPN intoxication has been advanced as a model for certain motor neuron degenerative diseases such as amyotropic lateral sclerosis (ALS) and hereditary canine spinal muscular atrophy (HCSMA).

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

3,3'-IMINODIPROPIONITRILE Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

Bis(2-cyanoethyl)amine is used as pharmaceutical intermediates.

General Description

Clear colorless liquid.

Air & Water Reactions

Water soluble. Moisture sensitive. Some 18-month old bottles of 3,3'-IMINODIPROPIONITRILE exploded, probably owing to slow hydrolysis and buildup of pressure. Solutions in water are unstable above pH 4. .

Reactivity Profile

Nitriles, such as 3,3'-IMINODIPROPIONITRILE, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

Fire Hazard

3,3'-IMINODIPROPIONITRILE is combustible.