1-BENZYLINDOLE-3-CARBOXYLIC ACID
- Product Name
- 1-BENZYLINDOLE-3-CARBOXYLIC ACID
- CAS No.
- 27018-76-4
- Chemical Name
- 1-BENZYLINDOLE-3-CARBOXYLIC ACID
- Synonyms
- RARECHEM AL BE 0270;1-benzyl-indole-3-carboxylicaci;1-BENZYLINDOLE-3-CARBOXYLIC ACID;INDOLE-3-CARBOXYLIC ACID, 1-BENZYL-;1-Benzylindole-3-carboxylicacid,95%;1-BENZYL-1H-INDOLE-3-CARBOXYLIC ACID;1-(phenylmethyl)indole-3-carboxylic acid;1-(phenylmethyl)-3-indolecarboxylic acid;1-(Phenylmethyl)-1H-indole-3-carboxylic acid;1-BENZYLINDOLE-3-CARBOXYLIC ACIDCRYSTALL INE
- CBNumber
- CB0390488
- Molecular Formula
- C16H13NO2
- Formula Weight
- 251.28
- MOL File
- 27018-76-4.mol
1-BENZYLINDOLE-3-CARBOXYLIC ACID Property
- Melting point:
- 195-196 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 496.3±28.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- form
- Solid
- pka
- 3.98±0.10(Predicted)
- Appearance
- Light yellow to brown Solid
- CAS DataBase Reference
- 27018-76-4(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- NL5995800
- HS Code
- 29339980
- Toxicity
- mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03773,
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B8875
- Product name
- 1-Benzylindole-3-carboxylic acid
- Packaging
- 1g
- Price
- $92.2
- Updated
- 2023/01/07
- Product number
- B194848
- Product name
- 1-Benzyl-1H-indole-3-carboxylicAcid
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 4669AH
- Product name
- 1-Benzylindole-3-carboxylic acid
- Packaging
- 1g
- Price
- $58.2
- Updated
- 2021/12/16
- Product number
- FB56800
- Product name
- 1-Benzylindole-3-Carboxylic Acid
- Packaging
- 2g
- Price
- $62
- Updated
- 2021/12/16
- Product number
- FB56800
- Product name
- 1-Benzylindole-3-Carboxylic Acid
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
1-BENZYLINDOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
Reactant for preparation of:• ;Indoleacetic acid analogs as differentiation-inducing and antiproliferative agents for human myeloblastoma cells1• ;Indole-carboxamide derivatives as inhibitors of lipid peroxidation and superoxide anion formation2• ;Indole carboxamides as hyaluronidase inhibitors3• ;Fuconojirimycin derivatives as inhibitors of α-fucosidases4• ;Indole-2 and 3-carboxamides as selective cyclooxygenase-2 inhibitors5• ;Indole amides as antihistaminic agents6
Uses
Reactant for preparation of:
- Indoleacetic acid analogs as differentiation-inducing and antiproliferative agents for human myeloblastoma cells
- Indole-carboxamide derivatives as inhibitors of lipid peroxidation and superoxide anion formation
- Indole carboxamides as hyaluronidase inhibitors
- Fuconojirimycin derivatives as inhibitors of α-fucosidases
- Indole-2 and 3-carboxamides as selective cyclooxygenase-2 inhibitors
- Indole amides as antihistaminic agents
Synthesis
100-39-0
27018-76-4
1. 0.50 g (3.10 mmol) 1H-indole-3-carboxylic acid was dissolved in 5 mL of anhydrous DMF under dry conditions and stirred until completely dissolved. 2. 0.27 g (6.75 mmol) of 60% NaH (dispersed in mineral oil) was added slowly and the reaction was stirred at room temperature for 30 minutes. 3. Add 0.39 mL (3.28 mmol) of benzyl bromide dropwise and continue stirring at room temperature for 1 hour. 4. The reaction mixture was slowly poured into ice water and extracted with ethyl acetate (3 × 10 mL). 5. The organic phases were combined, dried over anhydrous Na?SO?, filtered and concentrated under reduced pressure. 6. The residue was recrystallized from ether to give 0.61 g (78% yield) of white crystals of 1-benzyl-1H-indole-3-carboxylic acid. 7. The product was subjected to electrospray ionization mass spectrometry (ESI). 7. The product was characterized by electrospray ionization mass spectrometry (ES-MS): m/z 250 [M-H]?
References
[1] Patent: US2007/27173, 2007, A1. Location in patent: Page/Page column 35
[2] Tetrahedron Letters, 2014, vol. 55, # 51, p. 7114 - 7117
[3] Tetrahedron, 2016, vol. 72, # 5, p. 734 - 745
1-BENZYLINDOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
1-BENZYLINDOLE-3-CARBOXYLIC ACID Suppliers
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- Ukraine
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- Advantage
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View Lastest Price from 1-BENZYLINDOLE-3-CARBOXYLIC ACID manufacturers
- Product
- 1-BENZYLINDOLE-3-CARBOXYLIC ACID 27018-76-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 1-BENZYLINDOLE-3-CARBOXYLIC ACID 27018-76-4
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02