ChemicalBook > CAS DataBase List > (Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide

(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide

Product Name: (Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide
CAS No.: 140405-36-3
Chemical Name: (Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide
Synonyms: RSVA 405;RSVA405, 10 mM in DMSO;N'-(4-(Diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide;(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide;2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid;4-Pyridinecarboxylic acid, 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide;RSVA-405,Autophagy,Inhibitor,anti-inflammatory,STAT,AMP-activated protein kinase,disease,Kinase,RSVA405,obesity,Alzheimer's,STAT3,Protein,inhibit,I/R,AMPK,AMP-Activated
CBNumber: CB03921706
Molecular Formula: C17H20N4O2
Formula Weight: 312.37
MOL File: 140405-36-3.mol

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(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide Property

Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: <15.62mg/ml in DMSO
pka: 8.52±0.40(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5138
Product name: RSVA405
Purity: ≥98%(HPLC)
Packaging: 10
Price: $183
Updated: 2021/12/16

Tocris

Product number: 5138
Product name: RSVA405
Purity: ≥98%(HPLC)
Packaging: 50
Price: $694
Updated: 2021/12/16

Usbiological

Product number: 256530
Product name: RSVA 405
Packaging: 10mg
Price: $438
Updated: 2021/12/16

TRC

Product number: R701030
Product name: RSVA405
Packaging: 50mg
Price: $755
Updated: 2021/12/16

ChemScene

Product number: CS-0026035
Product name: RSVA405
Purity: 99.56%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

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(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide Chemical Properties,Usage,Production

Uses

RSVA 405 is a potent STAT3 inhibitor and is an analog of resveratol.

in vivo

RSVA405 (3 mg/kg; i.p.) attenuates renal injury and protects renal function after ischemia-reperfusion (I/R) in rats^[1].
RSVA405 (20-100 mg/kg/d; p.o. for 11 weeks) significantly reduces the body weight gain of mice fed a high-fat diet^[2].

Animal Model:	Male Sprague-Dawley rats (300-350 g) are induced I/R injury^[1]
Dosage:	3 mg/kg
Administration:	I.p. one hour before inducing I/R injury
Result:	Decreased the levels of creatinine and blood urea nitrogen (BUN), by 35.8% and 44.3% in serum, respectively. Decreased the levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) by 33.0% and 59.8% in serum, respectively.

IC 50

AMPK: 1 μM (EC₅₀, in cell-based assays)

(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide Suppliers

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140405-36-3, (Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazideRelated Search:

(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide

2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid

RSVA 405

RSVA-405,Autophagy,Inhibitor,anti-inflammatory,STAT,AMP-activated protein kinase,disease,Kinase,RSVA405,obesity,Alzheimer's,STAT3,Protein,inhibit,I/R,AMPK,AMP-Activated

4-Pyridinecarboxylic acid, 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide

N'-(4-(Diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide

RSVA405, 10 mM in DMSO

140405-36-3