ChemicalBook > CAS DataBase List > Spiramycin

Spiramycin

Product Name: Spiramycin
CAS No.: 8025-81-8
Chemical Name: Spiramycin
Synonyms: LEUCOMYCIN;espiramicin;Spiramycine;Spiramycin Ep;KITASAMYCIN BASE;5337r.p.;r.p.5337;rovamycin;nsc-64393;sequamycin
CBNumber: CB0396400
Molecular Formula: C43H74N2O14
Formula Weight: 843.05
MOL File: 8025-81-8.mol

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Spiramycin Property

Melting point:: 126-128 °C
Boiling point:: 914℃
alpha: D20 -80° (methanol)
refractive index: 81 ° (C=2, 10% AcOH)
Flash point:: >110°(230°F)
storage temp.: 2-8°C
solubility: ethanol: 50 mg/mL, clear to slightly hazy, light-yellow
form: powder
color: white to light yellow
optical activity: [α]/D -85 to -80° in water (Specific rotation (dry basis))
Water Solubility: Soluble in methanol. Slightly soluble in water
Merck: 14,8752
CAS DataBase Reference: 8025-81-8

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 1
RTECS: WG9400000
F: 10
HS Code: 29419090
Hazardous Substances Data: 8025-81-8(Hazardous Substances Data)
Toxicity: LD50 in rats (mg/kg): 9400 orally; 1000 s.c.; 170 i.v. (Sous)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S9132
Product name: Spiramycin
Packaging: 1g
Price: $112
Updated: 2025/07/31

Sigma-Aldrich

Product number: S1100000
Product name: Spiramycin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 200 mg
Price: $225
Updated: 2025/07/31

Sigma-Aldrich

Product number: 46745
Product name: Spiramycin from Streptomyces sp.
Purity: VETRANAL
Packaging: 100mg
Price: $59.4
Updated: 2025/07/31

TCI Chemical

Product number: S0575
Product name: Spiramycin
Purity: >90.0%(HPLC)
Packaging: 5g
Price: $116
Updated: 2025/07/31

TCI Chemical

Product number: S0575
Product name: Spiramycin
Purity: >90.0%(HPLC)
Packaging: 25g
Price: $400
Updated: 2025/07/31

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Spiramycin Chemical Properties,Usage,Production

Description

Spiramycin was found in the culture broth of Streptomyces ambofaciens by Rhone Poulenc in 1954 and its acetate was synthesized by Kyowa Hakko Kogyo Co. in 1965. This antibiotic consists of three closely related macrolide components, I, II, and III, whose ratio is 2 : 1 : 1. Spiramycin shows almost the same antimicrobial spectrum and activity as the other macrolides, but its acetate, acetylspiramycin, has much better pharmacokinetic properties and activity in vivo.

Chemical Properties

An antibiotic substance.

Originator

Rovamycine,Specia,France,1972

Uses

antibacterial

Uses

vitamin A

Uses

Spiramycin I (foromacidin A) is the major analogue of a complex of 16-membered macrocyclic lactones produced by S. ambofaciens and S. spiramyceticus that have broad spectrum antibiotic activity. Spiramycins are unusual among the macrocyclic lactones in that they contain two basic sugars. Spiramycin complex has been used in both human and animal health but its use has not been widespread.

Manufacturing Process

The process for producing spiramycin comprises inoculating an aqueous nutrient medium with a culture of the NRRL No. 2420, allowing aerobic fermentation to take place and separating from the culture medium the spiramycin thus formed. The culture medium also contains the antibiotic substance known as Congocidin which, however, does not possess the same useful properties as spiramycin and which can be isolated in crystalline form. The separation of the two antibiotic substances is readily achieved.

brand name

Rovamycin (Rhone-Poulenc Rorer).

Therapeutic Function

Antibacterial

Antimicrobial activity

Enterobacteriaceae are resistant. Spiramycin is also active against anaerobic species: Actinomyces israelii (MIC 2–4 mg/L), Cl. perfringens (MIC 2–8 mg/L) and Bacteroides spp. (MIC 4–14 mg/L). It is also active against Tox. gondii.

Hazard

Poison; moderately toxic; teratogen; muta- gen; can cause hypermotility, diarrhea, nausea, or vomiting.

Pharmaceutical Applications

A fermentation product of Streptomyces ambofaciens, composed of several closely related compounds. Spiramycin 1 is the major component (c. 63%); spiramycins 2 and 3 are the acetate and monopropionate esters, respectively. It is available for oral administration and as spiramycin adipate for intravenous infusion. Spiramycins are relatively stable in acid conditions. A derivative, acetylspiramycin, is available in Japan.

Pharmacokinetics

Oral absorption: Variable
Cmax 1 g oral： 2.8 mg/L after 2 h
Plasma half-life：4–8h
Volume of distribution ：383 L
Plasma protein binding ：15%
In healthy volunteers given 2 g orally followed by 1 g every 6 h, peak plasma levels were 1.0–6.7 mg/L. After 1 g orally the AUC was 10.8 mg.h/L, with an apparent elimination halflife of 2.8 h. It is widely distributed in the tissues. It does not reach the CSF. Levels 12 h after a dose of 1 g were 0.25 mg/L in serum, 5.3 mg/L in bone and 6.9 mg/L in pus. Levels of 10.6 mg/L have been found 4 h after dosing in saliva, and concentrations at least equal to those in the serum are seen in bronchial secretions. A concentration of 27 mg/g was found in prostate tissues after repeated dosage. Only 5–15% is recovered from the urine. Most is metabolized, but significant quantities are eliminated via the bile, in which concentrations up to 40 times those in the serum may be found.

Side effects

Spiramycin is generally well tolerated, the most common adverse reactions being gastrointestinal disturbances, notably abdominal pain, nausea and vomiting, rashes and sensitization following contact.

Spiramycin Preparation Products And Raw materials

Raw materials

Starch Peptone

Preparation Products

Acetylspiramycin

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Spiramycin Suppliers

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View Lastest Price from Spiramycin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Spiramycin 8025-81-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 96.0%-103.0%,EP97
Supply Ability: 200kg/month
Release date: 2025-04-28

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Spiramycin 8025-81-8
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-25

Hebei Chuanghai Biotechnology Co., Ltd

Product: Spiramycin 8025-81-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

8025-81-8, SpiramycinRelated Search:

SPIRAMYCIN BASE spiramycin ii,Spiramycin B (7CI, 8CI),Spiramycin II (6CI),spiramycin Alvespimycin SPIRAMYCIN EMBONATE Spiramycin, hexanedioate (1:1) (salt) ,SPIRAMYCIN ADIPATE,SPIRAMYCIN HEXANEDIOATE Spiramycin U SPIRAMYCIN III,Spiramycin C Spiramycin I-d3,Spiramycin A-d,Spiramycin A-d3 SPIRAMYCIN I STANDARD,Spiramycin A,SPIRAMYCIN I Spiramycin Speramycin EP spiramycin I 3-hydroxyl acylase SPIRAMYCIN A MIXTURE OF SPIR Spiramycin/SpiramycinEmbonate/SpiramycinAdipate Spiramycin, 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (ester)

SPIRAMYCIN

rovamycin

provamycin

FORMACIDINE

foromacidin

LEUCOMYCIN

KITASAMYCIN BASE

Spiramycin Ep

sequamycin

spiramycin from streptomyces sp.

Spiramycin solution

spiramycin standard solution

Spiramyein

Spiramycine

SPIRAMYCIN VETRANAL, 100 MG

SpiramycinBaseEp97

2-[12-[5-(4,5-Dihydroxy-4,6-dimethyl-oxan-2-yl)oxy-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-8-(5-dimethylamino-6-methyl-oxan-2-yl)oxy-14-hydroxy-13-methoxy-2,9-dimethyl-16-oxo-1-oxacyclohexadeca-4,6-dien-11-yl]acetaldehyde

Pharmagrade

Spiramycin,Formacidine

SpiraMycin API

SpiraMycin(SpiraMycin base)

SpiraMycin 0.1

foromacidine

2-[(4R,6S,7R,9R,10R,11E,13E,16R)-6-[[5-[(4,5-dihydroxy-4,6-dimethyl-2-oxanyl)oxy]-4-(dimethylamino)-3-hydroxy-6-methyl-2-oxanyl]oxy]-10-[[5-(dimethylamino)-6-methyl-2-oxanyl]oxy]-4-hydroxy-5-methoxy-9

5337r.p.

antibiotic799

espiramicin

nsc-64393

r.p.5337

rovamycine

Spiramycin Solution, 1000ppm

Spiramycin, >=3900 IU/mg

Spiramycin CRS

Spiramycin&gt

foromacidin spiramycin

Spiramycin USP/EP/BP

Spiramycin (S1100000)

*Spiramycin*Q: What is *Spiramycin* Q: What is the CAS Number of *Spiramycin* Q: What is the storage condition of *Spiramycin* Q: What are the applications of *Spiramycin*

3-Dihydrobenzofuranyl-5-acetic acid

High purity spiramycin

Spiramycin/Spiramycin alkaloids

Dopamine Impurity 60

Spiramycin in methanol

C16972900 Spiramycin

Spiramycin 100 μg/ml Methanol

Spiramycin in Acetonitrile

Spiramycin, 10 mM in DMSO

Spiramycin 1000 μg/mL in Acetonitrile

First International Standard for Spiramycin

8025-81-8

C40H67NO14

C43H74N2O14

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