2'-FLUORO[1,1'-BIPHENYL]-2-AMINE
- Product Name
- 2'-FLUORO[1,1'-BIPHENYL]-2-AMINE
- CAS No.
- 316-61-0
- Chemical Name
- 2'-FLUORO[1,1'-BIPHENYL]-2-AMINE
- Synonyms
- AKOS BAR-1334;2'-fluoro-biphenyl-2-ylamine;2'-FLUORO[1,1'-BIPHENYL]-2-AMINE;[1,1'-Biphenyl]-2-amine, 2'-fluoro-;TERT-BUTYL4-(2-(2-HYDROXYETHOXY)ETHYL)PIPERAZINE-3-CARBOXYLATE
- CBNumber
- CB0398217
- Molecular Formula
- C12H10FN
- Formula Weight
- 187.21
- MOL File
- Mol file
2'-FLUORO[1,1'-BIPHENYL]-2-AMINE Property
- Boiling point:
- 298.4±15.0 °C(Predicted)
- Density
- 1.161±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.89±0.10(Predicted)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F925908
- Product name
- 2''-Fluoro-[1,1''-biphenyl]-2-amine
- Packaging
- 50mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 021698
- Product name
- 2'-Fluoro[1,1'-biphenyl]-2-amine
- Packaging
- 500mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 021698
- Product name
- 2'-Fluoro[1,1'-biphenyl]-2-amine
- Packaging
- 1g
- Price
- $294
- Updated
- 2021/12/16
- Product number
- CHM0033193
- Product name
- 2'-FLUORO[1,1'-BIPHENYL]-2-AMINE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $802.73
- Updated
- 2021/12/16
- Product number
- A100532
- Product name
- 2'-Fluoro-[1,1'-biphenyl]-2-amine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $66
- Updated
- 2021/12/16
2'-FLUORO[1,1'-BIPHENYL]-2-AMINE Chemical Properties,Usage,Production
Synthesis
1993-03-9
615-36-1
316-61-0
The general procedure for the synthesis of 2'-fluoro-[1,1'-biphenyl]-2-amine from 2-fluorophenylboronic acid and o-bromoaniline was as follows: to a 20 mL Schlenk tube fitted with a magnetic stirrer were added sequentially o-bromoaniline (2 mmol), 2-fluorophenylboronic acid (2.4 mmol), K2CO3 (5 mmol), 10 mL of mixed solvent [H2O, H2O- MeOH (1:1), H2O-EtOH (1:1), H2O-EG (1:1)], and 0.01 M solution of the palladium complexes PdCl2(L)2 or Pd[(L)4]Cl2 in MeOH (0.001-0.2 mol%). The reaction mixture was placed in a preheated oil bath at temperatures selected according to the solvents: 100°C for MeOH-H2O, 110°C for EtOH-H2O, 140°C for pure H2O, and 160°C for EG-H2O; and stirred under reflux conditions for the indicated times. Upon completion of the reaction, the mixture was cooled to room temperature, acidified with 5 M HCl (if desired), and subsequently diluted with 10 mL of H2O and 10 mL of Et2O (or EtOAc). The organic phase was separated and the aqueous phase was extracted with Et2O (or EtOAc) (2 x 10 mL). The organic layers were combined and washed sequentially with H2O (10 mL), saturated saline (10 mL) and dried with anhydrous Na2SO4. Finally, the ether solution was filtered briefly through a silica gel pad and the solvent was evaporated to obtain the pure product 2'-fluoro-[1,1'-biphenyl]-2-amine.
References
[1] Catalysis Communications, 2016, vol. 79, p. 17 - 20
[2] Organic Letters, 2015, vol. 17, # 6, p. 1597 - 1600
2'-FLUORO[1,1'-BIPHENYL]-2-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2'-FLUORO[1,1'-BIPHENYL]-2-AMINE manufacturers
- Product
- 2'-FLUORO[1,1'-BIPHENYL]-2-AMINE 316-61-0
- Price
- US $1.00/G
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 500G
- Release date
- 2024-05-22