3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE
- Product Name
- 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE
- CAS No.
- 2436-29-5
- Chemical Name
- 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE
- Synonyms
- 3-Phthalimidylpropanal;N-(3-Oxopropyl)phthalimide;Phthalimidopropionaldehyde;3-(Phthalimid-1-yl)propanal;N-(2-Formylethyl)phthalimide;3-Phthalimidopropionaldehyde;Phthalimide, N-(2-formylethyl)-;beta-Phthalimidopropionaldehyde;.beta.-Phthalimidopropionaldehyde;3-(1,3-dioxoisoindol-2-yl)propanal
- CBNumber
- CB0400662
- Molecular Formula
- C11H9NO3
- Formula Weight
- 203.19
- MOL File
- 2436-29-5.mol
3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE Property
- Melting point:
- 136-141 ºC
- Boiling point:
- 352.7±25.0 °C(Predicted)
- Density
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- solid
- pka
- -2.24±0.20(Predicted)
- color
- White
- InChI
- InChI=1S/C11H9NO3/c13-7-3-6-12-10(14)8-4-1-2-5-9(8)11(12)15/h1-2,4-5,7H,3,6H2
- InChIKey
- IBSDSIHTMABATG-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2)C(=O)N1CCC=O
- CAS DataBase Reference
- 2436-29-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P350IF ON SKIN: Gently wash with plenty of soap and water.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
N-Bromosuccinimide Price
- Product number
- P2997
- Product name
- 3-(1,3-Dioxoisoindolin-2-yl)propanal
- Packaging
- 5G
- Price
- $85
- Updated
- 2025/07/31
- Product number
- P2997
- Product name
- 3-(1,3-Dioxoisoindolin-2-yl)propanal
- Packaging
- 25G
- Price
- $255
- Updated
- 2025/07/31
- Product number
- D487610
- Product name
- 3-(1,3-Dioxoisoindolin-2-yl)propanal
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D487610
- Product name
- 3-(1,3-Dioxoisoindolin-2-yl)propanal
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FD134496
- Product name
- 3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE Chemical Properties,Usage,Production
Description
3-(1,3-Dioxoisoindol-2-yl)propanal is an aldehyde organic compound, which can be used as a pharmaceutical intermediate.
Chemical Properties
White powdery crystal, which is easy to absorb moisture.
Uses
3-(1,3-Dioxoisoindol-2-yl)propanal is a key intermediate in the preparation of atorvastatin (Lipitor).
Synthesis
883-44-3
2436-29-5
Step 2. Preparation of 3-(1,3-dioxoisoindolin-2-yl)propanal A mixture of 2-(3-hydroxypropyl)isoindoline-1,3-dione (2.0 g, 8.76 mmol) with IBX (8.2 g, 29.27 mmol) in 60 mL of ethyl acetate (EA) was refluxed for 2 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated to afford 3-(1,3-dioxoisoindolin-2-yl)propionaldehyde (2.0 g, yield: 100%) as a white solid. NMR (500 MHz, CDCl3): δ 9.82 (s, 1H), 7.84-7.86 (m, 2H), 7.72-7.74 (m, 2H), 4.04 (t, J = 7.0 Hz, 2H), 2.87-2.89 (m, 2H) ppm. MS (ESI): m/z 553.7 [M + 1]+.
References
[1] Patent: WO2012/82436, 2012, A2. Location in patent: Page/Page column 245-246
[2] Organic and Biomolecular Chemistry, 2014, vol. 12, # 32, p. 6094 - 6104
[3] Journal of the American Chemical Society, 2006, vol. 128, # 12, p. 4023 - 4034
[4] Tetrahedron, 2002, vol. 58, # 9, p. 1719 - 1737
[5] Helvetica Chimica Acta, 2005, vol. 88, # 10, p. 2610 - 2616
3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE manufacturers
- Product
- 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propionaldehyde 2436-29-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE 2436-29-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 3-Phthalimidopropionaldehyde 2436-29-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10