5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
- Product Name
- 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
- CAS No.
- 493028-20-9
- Chemical Name
- 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
- Synonyms
- CBFβ Inhibitor;CBFβ Inhibitor;TIMTEC-BB SBB011699;Runx1-CBFβ interaction inhibitor 1;2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem;5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
- CBNumber
- CB0412427
- Molecular Formula
- C12H14N2OS
- Formula Weight
- 234.32
- MOL File
- Mol file
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Property
- Boiling point:
- 421.6±40.0 °C(Predicted)
- Density
- 1.192±0.06 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
- form
- Tan solid
- pka
- 5.00±0.10(Predicted)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
N-Bromosuccinimide Price
- Product number
- 16771
- Product name
- CBFβ Inhibitor
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 16771
- Product name
- CBFβ Inhibitor
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $135
- Updated
- 2024/03/01
- Product number
- 16771
- Product name
- CBFβ Inhibitor
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $301
- Updated
- 2024/03/01
- Product number
- C3398
- Product name
- CBFβInhibitor
- Packaging
- 25mg
- Price
- $342
- Updated
- 2021/12/16
- Product number
- 4241AE
- Product name
- 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
- Packaging
- 1g
- Price
- $432
- Updated
- 2021/12/16
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Chemical Properties,Usage,Production
Description
Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.
Uses
Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Suppliers
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