ChemicalBook > CAS DataBase List > 4-AMINO-1,3,5-TRIMETHYLPYRAZOLE

4-AMINO-1,3,5-TRIMETHYLPYRAZOLE

Product Name
4-AMINO-1,3,5-TRIMETHYLPYRAZOLE
CAS No.
28466-21-9
Chemical Name
4-AMINO-1,3,5-TRIMETHYLPYRAZOLE
Synonyms
1,3,5-TRIMETHYL-1H-PYRAZOL-4-AMINE;AKOS B000505;AKOS PAO-0230;1,3,5-?-1H--4-;BUTTPARK 29\06-78;ART-CHEM-BB B000505;TIMTEC-BB SBB006986;1,3,5-Trimethyl-4-pyrazolamine;1,3,5-trimethylpyrazol-4-amine;4-AMINO-1,3,5-TRIMETHYLPYRAZOLE
CBNumber
CB0412917
Molecular Formula
C6H11N3
Formula Weight
125.17
MOL File
28466-21-9.mol
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4-AMINO-1,3,5-TRIMETHYLPYRAZOLE Property

Melting point:
96 °C
Boiling point:
236℃
Density 
1.13
Flash point:
97℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
4.75±0.10(Predicted)
color 
Brown
BRN 
110739
InChI
InChI=1S/C6H11N3/c1-4-6(7)5(2)9(3)8-4/h7H2,1-3H3
InChIKey
SSDGMKHZMNTWLS-UHFFFAOYSA-N
SMILES
N1(C)C(C)=C(N)C(C)=N1
CAS DataBase Reference
28466-21-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
RTECS 
UQ6125100
HS Code 
2933199090
Toxicity
mouse,LD50,subcutaneous,> 500mg/kg (500mg/kg),Farmaco, Edizione Scientifica. Vol. 25, Pg. 592, 1970.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H360May damage fertility or the unborn child

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B535283
Product name
1,3,5-Trimethyl-1H-pyrazol-4-amine
Packaging
500mg
Price
$90
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-M7
Product name
4-Amino-1,3,5-trimethyl-1H-pyrazole
Packaging
250mg
Price
$29
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-M7
Product name
4-Amino-1,3,5-trimethyl-1H-pyrazole
Packaging
1g
Price
$47
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-M7
Product name
4-Amino-1,3,5-trimethyl-1H-pyrazole
Packaging
5G
Price
$180
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0017208
Product name
1,3,5-TRIMETHYL-1H-PYRAZOL-4-AMINE
Purity
95.00%
Packaging
1G
Price
$648.81
Updated
2021/12/16
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4-AMINO-1,3,5-TRIMETHYLPYRAZOLE Chemical Properties,Usage,Production

Definition

ChEBI: 1,3,5-Trimethyl-1H-pyrazol-4-amine is a member of pyrazoles.

Synthesis

1125-30-0

28466-21-9

General procedure for the synthesis of 4-amino-1,3,5-trimethylpyrazole from 4-nitro-1,3,5-trimethylpyrazole: To a solution of 1,3,5-trimethyl-4-nitro-1H-pyrazole (2.1 g, 1.35 mmol) in ethanol (30 mL) was added powdered iron (14.85 g, 27 mmol) and 6N aqueous hydrochloric acid solution (0.23 mL. 0.67 mmol) and the mixture was refluxed for 16 hours. After completion of the reaction (monitored by TLC), the solvent was removed by evaporation under reduced pressure. The crude product was alkalized with 0.5 N aqueous sodium hydroxide and extracted with 10% methanol-dichloromethane (10%, 50 mL) solution. The organic layer was dried with anhydrous sodium sulfate, filtered and the solvent evaporated to afford 4-amino-1,3,5-trimethylpyrazole as a beige solid (1.68 g, 99% yield).' HNMR (400 MHz, DMSO-d6): δ 3.50 (s, 3H), 3.27 (bs, 2H), 2.03 (s, 3H), 1.94 (s, 3H).

References

[1] Patent: WO2015/25197, 2015, A1. Location in patent: Paragraph 00095
[2] Patent: WO2015/113452, 2015, A1. Location in patent: Page/Page column 55
[3] Patent: EP1203767, 2002, A1. Location in patent: Example 39
[4] Chemische Berichte, 1895, vol. 28, p. 688
[5] Journal fuer Praktische Chemie (Leipzig), 1896, vol. <2> 53, p. 127

4-AMINO-1,3,5-TRIMETHYLPYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-1,3,5-TRIMETHYLPYRAZOLE Suppliers

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View Lastest Price from 4-AMINO-1,3,5-TRIMETHYLPYRAZOLE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
4-AMINO-1,3,5-TRIMETHYLPYRAZOLE 28466-21-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
4-AMINO-1,3,5-TRIMETHYLPYRAZOLE 28466-21-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

28466-21-9, 4-AMINO-1,3,5-TRIMETHYLPYRAZOLERelated Search:

4-AMINO-1,3,5-TRIMETHYLPYRAZOLE 1,3,5-Trimethylpyrazole 2-(3,5-DIMETHYL-4-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID ETHYL ESTER (3,5-DIMETHYL-4-NITRO-PYRAZOL-1-YL)-ACETIC ACID HYDRAZIDE 1-ETHYL-3-METHYL-4-NITRO-1H-PYRAZOLE-5-CARBOXYLIC ACID 2-(3,5-DIMETHYL-4-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID HYDRAZIDE 1-ACETYL-3(5)-(HEPTAFLUORO-1-PROPYL)-5(3)-METHYL-4-(NITRO)PYRAZOLE 1,3,5-TRIMETHYL-4-NITRO-1H-PYRAZOLE 3-(DIMETHYLAMINO)-2-(1,3-DIMETHYL-4-NITRO-1H-PYRAZOL-5-YL)ACRYLALDEHYDE O-METHYLOXIME 1-ACETYL-3(5)-(HEPTAFLUORO-1-PROPYL)-4-NITRO-5(3)-(PHENYL)PYRAZOLE N-[2-(1,3-DIMETHYL-4-NITRO-1H-PYRAZOL-5-YL)VINYL]-4-FLUOROANILINE ETHYL 2-OXO-2-[(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)AMINO]ACETATE N-(2,4-DIMETHOXYPHENYL)-N-[2-(1,3-DIMETHYL-4-NITRO-1H-PYRAZOL-5-YL)VINYL]AMINE 4-CHLORO-2-([2-(1,3-DIMETHYL-4-NITRO-1H-PYRAZOL-5-YL)VINYL]AMINO)BENZENOL 1-ACETYL-3(5)-TRIFLUOROMETHYL-4-NITRO-5(3)-(PHENYL)PYRAZOLE 1-ACETYL-3(5)-[1-(HEPTAFLUOROPROP-1-OXY)TETRAFLUOROETHYL]-5(3)-METHYL-4-(NITRO)PYRAZOLE N-[2-(1,3-DIMETHYL-4-NITRO-1H-PYRAZOL-5-YL)VINYL]-4-(TRIFLUOROMETHOXY)ANILINE 1-ACETYL-3(5)-TRIFLUOROMETHYL-5(3)-METHYL-4-(NITRO)PYRAZOLE

  • TIMTEC-BB SBB006986
  • AKOS PAO-0230
  • AKOS B000505
  • 4-AMINO-1,3,5-TRIMETHYLPYRAZOLE
  • 1,3,5-TRIMETHYL-1H-PYRAZOL-4-AMINE
  • 1,3,5-TRIMETHYL-1H-PYRAZOL-4-YLAMINE
  • BUTTPARK 29\06-78
  • ART-CHEM-BB B000505
  • 1H-pyrazol-4-amine, 1,3,5-trimethyl-
  • 4-Amino-1,3,5-trimethylpyrazole hydrochloride
  • 1,3,5-Trimethyl-4-pyrazolamine
  • 1,3,5-trimethylpyrazol-4-amine
  • Pyrazole, 4-amino-1,3,5-trimethyl-
  • 4-Amino-2,3,5-trimethyl-2H-pyrazole
  • 1,3,5-triMethyl-4-aMino-1H-pyrazole
  • (1,3,5-trimethylpyrazol-4-yl)amine
  • 4-amino-1,3,5-trimethyl-pyrazol
  • 1,3,5-?-1H--4-
  • 28466-21-9
  • AMINO