Lorlatinib acetate

Product Name: Lorlatinib acetate
CAS No.: 1924207-18-0
Chemical Name: Lorlatinib acetate
Synonyms: Lorlatinib acetate
CBNumber: CB04189031
Molecular Formula: C23H23FN6O4
Formula Weight: 466.47
MOL File: 1924207-18-0.mol

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Lorlatinib acetate Property

storage temp.: room temp
solubility: DMSO: 2mg/mL, clear
form: powder
color: white to beige
optical activity: [α]/D -95 to -115°, c =0.5 in methanol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0271
Product name: PF-06463922 acetate
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $100
Updated: 2025/07/31

Sigma-Aldrich

Product number: PZ0039
Product name: Lorlatinib
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $117.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: PZ0039
Product name: Lorlatinib
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $423
Updated: 2025/07/31

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Lorlatinib acetate Chemical Properties,Usage,Production

Uses

PF-06463922 acetate has been used as an inhibitor of anaplastic lymphoma kinase (ALK) to analyze the expression of adrenomedullin using qPCR.

Biological Activity

PF-06463922 is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong activity against all known ALK and ROS1 mutants identified in patients with crizotinib-resistant disease. PF-06463922 is in clinical trials for the treatment of non–small cell lung cancer (NSCLC).

in vivo

In rats, Lorlatinib (PF-06463922) displays low plasma clearance, a moderate volume of distribution, a reasonable half-life, low propensity for p-glycoprotein 1-mediated efflux and a bioavailability of 100%^[1]. In vivo, Lorlatinib shows cytoreductive antitumor efficacy in the NIH3T3 xenograft models expressing human CD74-ROS1 and Fig-ROS1 via inhibition in ROS1 phosphorylation and the downstream signaling molecules, as well as inhibition of the cell cycle protein Cyclin D1 in tumors. Lorlatinib also demonstrates marked antitumor activity in mice bearing tumor xenografts expressing EML4-ALK, EML4-ALK-L1196M, EML4-ALK-G1269A, EML4-ALK-G1202R or NPM-ALK^[2].

Lorlatinib acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Lorlatinib acetate Suppliers

China 9 Global 9

ShangHai Biochempartner Co.,Ltd

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Lorlatinib acetate

1924207-18-0