ChemicalBook > CAS DataBase List > ML162
ML162
- Product Name
- ML162
- CAS No.
- 1035072-16-2
- Chemical Name
- ML162
- Synonyms
- ML162;ML162, 10 mM in DMSO;2-Thiopheneacetamide, α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-;2-Chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide;2-Chloro-N-(3-chloro-4-methoxyphenyl)-N-{2-oxo-2-[(2-phenylethyl)amino]-1-(2-thienyl)ethyl}acetamide;p62,Glutathione Peroxidase,GPX4,ML-162,Nrf2,anticancer,HRAS,Ferroptosis,Inhibitor,inhibit,ML 162,ML162
- CBNumber
- CB04203599
- Molecular Formula
- C23H22Cl2N2O3S
- Formula Weight
- 477.40338
- MOL File
- 1035072-16-2.mol
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ML162 Property
- Boiling point:
- 699.3±55.0 °C(Predicted)
- Density
- 1.342±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF:10.0(Max Conc. mg/mL);20.95(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);52.37(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.09(Max Conc. mM) - form
- A crystalline solid
- pka
- 13.84±0.46(Predicted)
- color
- Off-white to light yellow
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML2561
- Product name
- ML162
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $100
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML2561
- Product name
- ML162
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $406
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 20455
- Product name
- ML-162
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $46
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 20455
- Product name
- ML-162
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $31
- Updated
- 2023/06/20
Cayman Chemical
- Product number
- 20455
- Product name
- ML-162
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $92
- Updated
- 2024/03/01
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ML162 Chemical Properties,Usage,Production
Description
ML-162 is an inhibitor of glutathione peroxidase 4 (GPX4) and decreases GPX4 levels in MDA-MB-231 breast cancer cells, as well as the viability of BT-549 breast cancer cells.
Uses
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines[1][2]
storage
Store at -20°C
References
[1] Michel We?wer, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. DOI:10.1016/j.bmcl.2011.09.047
[2] Daiha Shin, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462. DOI:10.1016/j.freeradbiomed.2018.10.426
ML162 Preparation Products And Raw materials
Raw materials
Preparation Products
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ML162 Suppliers
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