1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL
- Product Name
- 1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL
- CAS No.
- 96960-92-8
- Chemical Name
- 1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL
- Synonyms
- 1-C16-2-C1 DG;HEXADECYL METHYL GLYCEROL;3-methoxynonadecane-1,2-diol;1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL;1-O-hexadecyl-2-O-Methyl-sn-glycerol (PMG);1-Propanol, 3-(hexadecyloxy)-2-methoxy-, (2S)-;1-O-hexadecyl-2-O-methyl-sn-glycerol (PMG);1-O-Hexadecyl-2-O-methyl-sn-glycerol≥ 98% (HPLC);1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL (PMG);1-C16-2-C1 DG;1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL (PMG);1-C16-2-C1 DG
- CBNumber
- CB0422354
- Molecular Formula
- C20H42O3
- Formula Weight
- 330.55
- MOL File
- 96960-92-8.mol
1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL Property
- Melting point:
- 35-36 °C
- Boiling point:
- 430.6±25.0 °C(Predicted)
- Density
- 0.895±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- ≤8.3mg/ml in DMSO;8.3mg/ml in dimethyl formamide
- form
- solution in ethanol.
- pka
- 14.20±0.10(Predicted)
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H350May cause cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313IF exposed or concerned: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 60930
- Product name
- Hexadecyl Methyl Glycerol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 60930
- Product name
- Hexadecyl Methyl Glycerol
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 60930
- Product name
- Hexadecyl Methyl Glycerol
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- H290900
- Product name
- 1-O-Hexadecyl-2-O-methyl-sn-glycerol
- Packaging
- 10mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- C5388
- Product name
- HexadecylMethylGlycerol
- Packaging
- 100mg(solution)
- Price
- $123
- Updated
- 2021/12/16
1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
Hexadecyl methyl glycerol is a synthetic diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. It inhibits protein kinase C activity in human neutrophils, resulting in prevention of the respiratory burst induced by both phorbol 12,13-dibutyrate and fMLP.
Uses
1-O-Hexadecyl-2-O-methyl-sn-glycerol inhibits protein kinase C activity in human neutrophils.
Definition
ChEBI: 1-O-palmityl-2-O-methyl-sn-glycerol is an alkylglycerol having palmityl (hexadecyl) and methyl groups located at position2 1 and 2 respectively (the S-enantiomer).
Biological Activity
hexadecyl methyl glycerol, also known as amg-c16 with a hexadecyl chain at the sn-1 position, is a novel inhibitor of protein kinase c with ic50 value of about 80 μm [1].protein kinase c is a phospholipid-dependent kinase and the intracellular receptor for phorbol 12-myristate-13-acetate (pma), a substance that activates both the respiratory burst and protein kinase c. pkc enzymes are activated by signals such as increases in the concentration of diacylglycerol (dag) or calcium ions (ca2+) [1].hexadecyl methyl glycerol is a structural analog of diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. hexadecyl methyl glycerol inhibited the activation of purified protein kinase c by diacylglycerol in the presence of phosphatidylserine. in neutrophilic granulocytes, hexadecyl methyl glycerol inhibited the respiratory burst induced by pdbu in a dose-dependent way. in neutrophils, hexadecyl methyl glycerol inhibited the phosphorylation of purified 47-kda protein, an important substrate of protein kinase c [1].
References
[1]. kramer im1, van der bend rl, tool at, et al. 1-o-hexadecyl-2-q-methylglycerol, a novel inhibitor of protein kinase c, inhibits the respiratory burst in human neutrophils. j biol chem. 1989 apr 5;264(10):5876-84.
1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL Preparation Products And Raw materials
Raw materials
Preparation Products
1-O-HEXADECYL-2-O-METHYL-SN-GLYCEROL Suppliers
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 17687
- Advantage
- 55
- Tel
- 400-1166-196 18502815961
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14603
- Advantage
- 60
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52693
- Advantage
- 58
- Tel
- +86-0571-81612335 +8613336028439
- sales@nextpeptide.com
- Country
- China
- ProdList
- 19908
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 021-021-61109150
- Fax
- 021-61105897
- sales@tcisct.com
- Country
- China
- ProdList
- 31121
- Advantage
- 58
- Tel
- 400-400-8210725
- malulu@leyan.com
- Country
- China
- ProdList
- 39988
- Advantage
- 58
- Tel
- 400-1107768 15058188853
- Fax
- 0571-88150696
- 478133536@qq.com
- Country
- China
- ProdList
- 8552
- Advantage
- 58