4,6-DICHLORO-NICOTINAMIDE
- Product Name
- 4,6-DICHLORO-NICOTINAMIDE
- CAS No.
- 70593-57-6
- Chemical Name
- 4,6-DICHLORO-NICOTINAMIDE
- Synonyms
- Benzopyrene Impurity 6;4,6-DICHLORO-NICOTINAMIDE;4,6-DICHLORONICOTINAMIDE >95%;4,6-Dichloropyridin-3-carboxamide;4,6-DICHLOROPYRIDINE-3-CARBOXAMIDE;3-Pyridinecarboxamide, 4,6-dichloro-;4,6-DICHLORO-NICOTINAMIDE ISO 9001：2015 REACH
- CBNumber
- CB0423715
- Molecular Formula
- C6H4Cl2N2O
- Formula Weight
- 191.01
- MOL File
- 70593-57-6.mol
4,6-DICHLORO-NICOTINAMIDE Property
- Melting point:
- 153-155°
- Boiling point:
- 302.9±42.0 °C(Predicted)
- Density
- 1.524
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 13.91±0.50(Predicted)
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D435643
- Product name
- 4,6-Dichloronicotinamide
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- D435643
- Product name
- 4,6-Dichloronicotinamide
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- J96298
- Product name
- 4,6-Dichloronicotinamide
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FD139512
- Product name
- 4,6-Dichloronicotinamide
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FD139512
- Product name
- 4,6-Dichloronicotinamide
- Packaging
- 25g
- Price
- $250
- Updated
- 2021/12/16
4,6-DICHLORO-NICOTINAMIDE Chemical Properties,Usage,Production
Uses
4,6-Dichloronicotinamide
Synthesis
73027-79-9
70593-57-6
General procedure for the synthesis of 4,6-dichloropyridine-3-amide from 4,6-dichloronicotinic acid: oxalyl chloride (7.70 mL, 88.3 mmol) was slowly added to a suspension of 4,6-dichloronicotinic acid (8.47 g, 44.1 mmol) in dimethylformamide (200 mL) over a period of 1 h. The reaction was carried out at room temperature. After addition, the reaction mixture was continued to be stirred at room temperature for 3 hours, followed by vacuum concentration. The residue was dissolved in dichloromethane (200 mL), followed by the slow dropwise addition of ammonia (8.3 mL, 130 mmol) over a period of 30 minutes [Note: the addition of ammonia triggers an exothermic reaction, and the rate of dropwise acceleration needs to be controlled to ensure that the reaction temperature does not exceed 25°C]. After dropwise addition, the reaction mixture was continued to be stirred at room temperature for 1 hour, after which it was diluted with water (600 mL) and extracted with ethyl acetate (4 x 600 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated to afford 4,6-dichloropyridin-3-amide as a light brown solid (8.05 g, 95% yield). The product was used for subsequent reactions without further purification.1H NMR (400 MHz, d6-DMSO) δ 8.48 (s, 1H), 8.10 (br s, 1H), 7.87 (br s, 2H).
References
[1] Patent: US2015/291629, 2015, A1. Location in patent: Paragraph 1173-1174
[2] Patent: US2006/217417, 2006, A1. Location in patent: Page/Page column 12; 13
4,6-DICHLORO-NICOTINAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-DICHLORO-NICOTINAMIDE manufacturers
- Product
- 4,6-DICHLORO-NICOTINAMIDE 70593-57-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03
- Product
- 4,6-DICHLORO-NICOTINAMIDE 70593-57-6
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 85.0-99.8%
- Supply Ability
- 20tons
- Release date
- 2020-01-08