4-BROMO-3-PHENYLPYRIDINE

Product Name: 4-BROMO-3-PHENYLPYRIDINE
CAS No.: 440112-20-9
Chemical Name: 4-BROMO-3-PHENYLPYRIDINE
Synonyms: 3-Iodopyridin-2(2H)-one;4-BROMO-3-PHENYLPYRIDINE;Pyridine, 4-bromo-3-phenyl-
CBNumber: CB0429959
Molecular Formula: C11H8BrN
Formula Weight: 234.09
MOL File: 440112-20-9.mol

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4-BROMO-3-PHENYLPYRIDINE Property

Boiling point:: 318.1±22.0 °C(Predicted)
Density: 1.426±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.15±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0012937
Product name: 4-BROMO-3-PHENYLPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $500.76
Updated: 2021/12/16

Crysdot

Product number: CD11123243
Product name: 4-Bromo-3-phenylpyridine
Purity: 98%
Packaging: 1g
Price: $560
Updated: 2021/12/16

Chemenu

Product number: CM171736
Product name: 4-bromo-3-phenylpyridine
Purity: 98%
Packaging: 1g
Price: $585
Updated: 2021/12/16

Crysdot

Product number: CD11123243
Product name: 4-Bromo-3-phenylpyridine
Purity: 98%
Packaging: 250mg
Price: $225
Updated: 2021/12/16

SynChem

Product number: SC-41992
Product name: 4-BROMO-3-PHENYLPYRIDINE
Purity: 95%
Packaging: 1g
Price: $380
Updated: 2021/12/16

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4-BROMO-3-PHENYLPYRIDINE Chemical Properties,Usage,Production

Synthesis

591-50-4

19524-06-2

440112-20-9

General procedure for the synthesis of 4-bromo-3-phenylpyridine from iodobenzene and 4-bromopyridine hydrochloride: 4-bromopyridine hydrochloride (1-BA-2, 1 g, 5.14 mmol) was dissolved in 5.1 mL of tetrahydrofuran (THF), and the resulting solution was cooled to -78 °C. Lithium diisopropylammonium (LDA, 10.28 mL of 1 M THF solution) was added slowly over 10 min and the reaction mixture changed color to brown. After stirring for 30 minutes, zinc chloride (ZnCl2, 10.3 mL of a 0.5 M THF solution) was added over 10 minutes and the resulting mixture was stirred for 10 minutes and then slowly warmed to room temperature. Subsequently, iodobenzene (0.229 mL, 2.06 mmol) and tetrakis(triphenylphosphine)palladium (Pd(PPh3)4, 593 mg, 0.514 mmol) were added, and the reaction mixture was stirred under reflux conditions for 2 hours. After completion of the reaction, the reaction mixture was diluted with saturated aqueous ammonium chloride solution and extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford the target product 4-bromo-3-phenylpyridine (2-BA-2, 741 mg, 62% yield); LCMS detection showed the molecular ion peak m/z of 234.0 ([M+H]+).

References

[1] Patent: WO2011/79114, 2011, A1. Location in patent: Page/Page column 113; 114
[2] Synlett, 2002, # 5, p. 808 - 810

4-BROMO-3-PHENYLPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-3-PHENYLPYRIDINE Suppliers

China 31 Germany 1 India 1 Switzerland 1 United States 4 Global 38

Cochemical Ltd.

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440112-20-9, 4-BROMO-3-PHENYLPYRIDINERelated Search:

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4-BROMO-3-PHENYLPYRIDINE

Pyridine, 4-bromo-3-phenyl-

3-Iodopyridin-2(2H)-one

440112-20-9

C11H8BrN