ChemicalBook > CAS DataBase List > 4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name
4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.
132710-90-8
Chemical Name
4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms
1-Boc-4-(3-hydroxypropyl)piperazine,97%;tert-Butyl 4-(2-hydroxypropyl)piperazine-1-carboxylate;tert-Butyl 4-(3-hydroxy-propyl)-1-piperazinecarboxylate;1-Boc-4-(3-hydroxypropyl)piperazine;1,1-Dimethylethyl 4-(3-hydroxypropyl)-1-piperazinecarboxylate;4-(2-HYDROXYPROPYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER;1-Piperazinecarboxylic acid, 4-(3-hydroxypropyl)-, 1,1-dimethylethyl ester
CBNumber
CB0430292
Molecular Formula
C12H24N2O3
Formula Weight
244.33
MOL File
132710-90-8.mol
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4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Melting point:
73-77 °C (lit.)
Boiling point:
355.8±37.0 °C(Predicted)
Density 
1.074±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
15.10±0.10(Predicted)
form 
Solid
Appearance
White to off-white Solid
CAS DataBase Reference
132710-90-8
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
HazardClass 
6.1
HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
643467
Product name
1-Boc-4-(3-hydroxypropyl)piperazine
Purity
97%
Packaging
5g
Price
$38.65
Updated
2025/07/31
Sigma-Aldrich
Product number
643467
Product name
1-Boc-4-(3-hydroxypropyl)piperazine
Purity
97%
Packaging
25g
Price
$294
Updated
2025/07/31
TRC
Product number
T135833
Product name
tert-Butyl4-(3-Hydroxypropyl)piperazine-1-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
T135833
Product name
tert-Butyl4-(3-Hydroxypropyl)piperazine-1-carboxylate
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-737
Product name
tert-Butyl 4-(3-hydroxypropyl)piperazine-1-carboxylate
Purity
97.0%
Packaging
250mg
Price
$55
Updated
2021/12/16
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4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

5317-32-8

24424-99-5

132710-90-8

GENERAL STEPS: 3-(Piperazin-1-yl)propan-1-ol (1.44 g, 10 mmol), di-tert-butyl dicarbonate (3.3 g, 15 mmol), and N,N-diisopropylethylamine (1.80 g, 15 mmol) were dissolved in dichloromethane (100 mL) and stirred at room temperature until the reaction was complete. After the reaction was complete, the reaction mixture was diluted with dichloromethane (200 mL). The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by column chromatography (eluent: dichloromethane/methanol = 20:1) to afford tert-butyl 4-(3-hydroxypropyl)piperazine-1-carboxylate as a colorless oil (2.4 g, 97% yield).

References

[1] Patent: WO2015/120049, 2015, A1. Location in patent: Page/Page column 137
[2] Patent: WO2016/191172, 2016, A1. Location in patent: Page/Page column 83
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 15, p. 6516 - 6527
[4] Patent: WO2009/10491, 2009, A1. Location in patent: Page/Page column 56
[5] Patent: US2009/99172, 2009, A1. Location in patent: Page/Page column 29

4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 69 India 4 Switzerland 1 United Kingdom 1 United States 12 Global 87
Alfa Aesar
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View Lastest Price from 4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
Product
4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 132710-90-8
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
98%
Supply Ability
100kg
Release date
2023-03-09

132710-90-8, 4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

4-(5-Nitro-pyridin-2-yloxy)-piperidine-1-carboxylic acid tert-butyl ester 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester tert-Butyl 4-((6-bromopyridin-3-yl)methyl)piperazine-1-carboxylate tert-Butyl 4-(4-amino-2-fluorophenyl)piperidine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester tert-butyl 4-(6-bromopyridin-3-yl)piperazine-1-carboxylate tert-butyl 4-((6-aminopyridin-3-yl)methyl)piperazine-1-carboxylate tert-butyl 4-(aMinoMethyl)-4-cyanopiperidine-1-carboxylate tert-Butyl 4-[(5-aminopyridin-2-yl)oxy]piperidine-1-carboxylate 4-(2-Amino-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate tert-butyl 4-(3-bromo-6-chloropyridin-2-yl)piperazine-1-carboxylate tert-butyl 4-(4-amino-3-(trifluoromethyl)phenyl)piperazine-1-carboxylate tert-butyl 4-(4-amino-2,6-difluorophenyl)piperazine-1-carboxylate tert-butyl 4-(3-fluoro-4-nitrophenyl)piperazine-1-carboxylate tert-Butyl 4-(5-fluoro-2-nitrophenyl)-piperazine-1-carboxylate tert-butyl 4-(3-phenylpropyl)piperazine-1-carboxylate tert-butyl 4-(3-amino-5-(trifluoromethyl)phenyl)piperazine-1-carboxylate

  • tert-Butyl 4-(2-hydroxypropyl)piperazine-1-carboxylate
  • 1-<WBR>Boc-<WBR>4-<WBR>(3-<WBR>hydroxypropyl)<WBR>piperazine
  • 4-(2-HYDROXYPROPYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
  • 1-Piperazinecarboxylic acid, 4-(3-hydroxypropyl)-, 1,1-dimethylethyl ester
  • 1-Boc-4-(3-hydroxypropyl)piperazine,97%
  • 1,1-Dimethylethyl 4-(3-hydroxypropyl)-1-piperazinecarboxylate
  • tert-Butyl 4-(3-hydroxy-propyl)-1-piperazinecarboxylate
  • 132710-90-8
  • API intermediates