ChemicalBook > CAS DataBase List > 3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE

3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE

Product Name: 3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE
CAS No.: 657-15-8
Chemical Name: 3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE
Synonyms: (3-Nitrobenzoyl)trifluoromethane;α,α,α-Trifluoro-3'-nitroacetophenone;3'-Nitro-α,α,α-trifluoroacetophenone;2,2,2-Trifluoro-3'-nitroacetophenone;3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE;2,2,2-trifluoro-1-(3-nitrophenyl)ethanone;2,2-Trifluoro-1-(3-nitrophenyl)ethan-1-one;Ethanone, 2,2,2-trifluoro-1-(3-nitrophenyl)-;2,2,2-trifluoro-1-(3-nitrophenyl)ethan-1-one;m-Nitro-alpha,alpha,alpha-trifluoroacetophenone
CBNumber: CB0438940
Molecular Formula: C8H4F3NO3
Formula Weight: 219.12
MOL File: 657-15-8.mol

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3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE Property

Melting point:: 54.0 to 58.0 °C
Boiling point:: 113°C/12mmHg(lit.)
Density: 1.468±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
color: White to Light yellow to Green

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Safety

HS Code: 2914390090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: KOB0160
Product name: 8-Bromo-1,2-dihydroquinolin-2-one
Packaging: 1g
Price: $167
Updated: 2023/06/20

TCI Chemical

Product number: T3426
Product name: 2,2,2-Trifluoro-3'-nitroacetophenone
Purity: >98.0%(GC)
Packaging: 1g
Price: $94
Updated: 2025/07/31

TCI Chemical

Product number: T3426
Product name: 2,2,2-Trifluoro-3'-nitroacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $280
Updated: 2025/07/31

TRC

Product number: T900250
Product name: 2,2,2-trifluoro-1-(3-nitrophenyl)ethan-1-one
Packaging: 50mg
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 087884
Product name: 2,2,2-Trifluoro-1-(3-nitrophenyl)ethan-1-one
Purity: >97%
Packaging: 500mg
Price: $64
Updated: 2021/12/16

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3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE Chemical Properties,Usage,Production

Synthesis

434-45-7

657-15-8

General procedure for the synthesis of 2,2,2-trifluoro-1-(3-nitrophenyl)ethanone from 2,2,2-trifluoroacetophenone: 1. 20.0 g (114.9 mmol) of 2,2,2-trifluoroacetophenone was added to 80 mL of concentrated hydrochloric acid and the mixture was cooled to -10 °C. 2. a solution of 4.8 mL (114.8 mmol) of nitric acid dissolved in 20 mL of concentrated hydrochloric acid was pre-prepared at -10°C. 3. add the nitric acid solution dropwise slowly to the reaction mixture, controlling the reaction temperature to not exceed -5°C. 4. After the dropwise addition was completed, the reaction mixture was stirred at -10°C to 0°C for 1 hour. 5. Deionized water was carefully added, followed by adjusting the pH of the mixture to 9-10 with 50% aqueous sodium hydroxide solution. 6. The mixture was extracted three times with ethyl acetate, the organic phases were combined and dried over magnesium sulfate. 7. The organic phase was concentrated under pressure and the residue was purified by silica gel chromatography (mobile phase gradient: initially 2:1 cyclohexane/dichloromethane, progressively to 1:1 and finally pure dichloromethane). 8. 19.2 g of the target product was obtained in 76.2% yield. LC-MS (Method 6): rt = 0.81 min; m/z = 236. GC-MS (Method 1): Rt = 3.19 min; m/z = 150 (M-CF3)+.

References

[1] Patent: WO2013/100632, 2013, A1. Location in patent: Page/Page column 89; 90
[2] Patent: US2014/371219, 2014, A1. Location in patent: Paragraph 0624; 0625; 0626
[3] Patent: US2011/130445, 2011, A1. Location in patent: Page/Page column 64
[4] Patent: WO2016/131098, 2016, A1. Location in patent: Page/Page column 155
[5] Doklady Chemistry, 1985, vol. 281, p. 130 - 133

3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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657-15-8, 3'-NITRO-2,2,2-TRIFLUOROACETOPHENONERelated Search:

3-Nitroacetophenone Trifluoromethane 4'-Dioctylamino-2-nitro-4-trifluoroacetylazobenzene 2,2-DIFLUOROACETOPHENONE 1,1,1-Trifluoroacetone 2'-FLUOROACETOPHENONE Fluoroacetone Trifluoroacetophenone 3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE

3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE

2,2,2-trifluoro-1-(3-nitrophenyl)ethan-1-one

(3-Nitrobenzoyl)trifluoromethane

3'-Nitro-α,α,α-trifluoroacetophenone

α,α,α-Trifluoro-3'-nitroacetophenone

2,2,2-trifluoro-1-(3-nitrophenyl)ethanone

m-Nitro-alpha,alpha,alpha-trifluoroacetophenone

2,2,2-Trifluoro-3'-nitroacetophenone

Ethanone, 2,2,2-trifluoro-1-(3-nitrophenyl)-

2,2-Trifluoro-1-(3-nitrophenyl)ethan-1-one

1H-Benzimidazole-6-carboxylicacid,6-(methylthio)-

657-15-8

C8H4F3NO3