OCTANOIC-D15 ACID

OCTANOIC-D15 ACID Property

Melting point:

16 °C(lit.)

Boiling point:

237 °C(lit.)

Density 

1.005 g/mL at 25 °C

refractive index 

n20/D 1.4245(lit.)

Flash point:

>230 °F(lit.)

storage temp. 

Store at -20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml

form 

Liquid

color 

Colorless to light yellow

CAS Number Unlabeled

124-07-2

Safety

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-27-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

OCTANOIC-D15 ACID Chemical Properties,Usage,Production

Description

Octanoic acid-d₁₅ is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk. Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC₈₀s = <125, <125, 1,403, and 2,294 μM, respectively). Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.

Uses

Octanoic acid-D15 is a labelled analogue of Octanoic acid .

References

[1] HELENI MALLATOU  Theophilos M  Eleni Pappa. Changes in free fatty acids during ripening of Teleme cheese made with ewes’, goats’, cows’ or a mixture of ewes’ and goats’ milk[J]. International Dairy Journal, 2003, 13 2: Pages 211-219. DOI: 10.1016/s0958-6946(02)00153-x
[2] CHIFU B. HUANG. Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms[J]. Archives of oral biology, 2011, 56 7: Pages 650-654. DOI: 10.1016/j.archoralbio.2011.01.011
[3] W. ONKENHOUT. Identification and quantification of intermediates of unsaturated fatty acid metabolism in plasma of patients with fatty acid oxidation disorders.[J]. Clinical chemistry, 1995, 41 10 1: 1467-1474. DOI: 10.1093/clinchem/41.10.1467
[4] P RINALDO. Medium-chain acyl-CoA dehydrogenase deficiency. Diagnosis by stable-isotope dilution measurement of urinary n-hexanoylglycine and 3-phenylpropionylglycine.[J]. New England Journal of Medicine, 1988, 319 20: 1308-1313. DOI: 10.1056/nejm198811173192003