Lanthanum Carbonate Property

Density 

3.48[at 20℃]

Water Solubility 

1.24mg/L at 20℃

InChI

InChI=1S/3CH2O3.2La/c3*2-1(3)4;;/h3*(H2,2,3,4);;/q;;;2*+3/p-6

InChIKey

NZPIUJUFIFZSPW-UHFFFAOYSA-H

SMILES

[La+3].[La+3].C([O-])(=O)[O-].C([O-])(=O)[O-].C([O-])(=O)[O-]

CAS DataBase Reference

587-26-8

EPA Substance Registry System

Carbonic acid, lanthanum(3+) salt (3:2) (587-26-8)

Safety

Hazardous Substances Data

587-26-8(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Lanthanum Carbonate Chemical Properties,Usage,Production

Uses

Treatment of hyperphosphatae mia in patients with end stage renal disease.

brand name

Fosrenol (Shire).

Flammability and Explosibility

Not classified

Mechanism of action

Lanthanum Carbonate inhibits phosphate absorption from the intestine and lowers the phosphate levels in the blood. Lanthanum Carbonate inhibits phosphate absorption from the intestine and lowers the phosphate levels in the blood.

Side effects

Nausea, Vomiting, Abdominal pain

in vitro

Lanthanum carbonate is an ideal phosphate binder. It prevents the adsorption of dietary phosphate by forming insoluble lanthanum phosphate. It has been reported that lanthanum carbonate binds phosphate optimally at pH 3–5, while retaining binding activity at pH 1–7. In vitro, studies suggest that the efficacy of lanthanum phosphate is comparable to that of aluminium compounds in binding with phosphate. The FDA has approved using lanthanum carbonate as a phosphate binder for renal failure patients.