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MYXOTHIAZOL

Product Name
MYXOTHIAZOL
CAS No.
76706-55-3
Chemical Name
MYXOTHIAZOL
Synonyms
Myxothiazo;MYXOTHIAZOL;5-dimethoxy-4-methyl-;myxothiazolfrommyxobacterium;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;myxothiazol from myxobacterium*myxococcus fulvus;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
CBNumber
CB0453976
Molecular Formula
C25H33N3O3S2
Formula Weight
487.68
MOL File
76706-55-3.mol
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MYXOTHIAZOL Property

Boiling point:
679.6±65.0 °C(Predicted)
Density 
1.158±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow
form 
Solid
pka
14.07±0.50(Predicted)
color 
White to off-white
biological source
Myxococcus fulvus Mx f85
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Safety

Hazard Codes 
T+
Risk Statements 
28
Safety Statements 
28-36/37-45
RIDADR 
UN 3462 6.1/PG 1
WGK Germany 
3
RTECS 
QH7580000
F 
10
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T5580
Product name
Myxothiazol
Purity
from Myxococcus fulvus Mx f85, ≥98% (HPLC)
Packaging
1mg
Price
$114
Updated
2025/07/31
Sigma-Aldrich
Product number
T5580
Product name
Myxothiazol
Purity
from Myxococcus fulvus Mx f85, ≥98% (HPLC)
Packaging
5mg
Price
$456
Updated
2025/07/31
ChemScene
Product number
CS-0043613
Product name
Myxothiazol
Purity
≥99.0%
Packaging
1mg
Price
$290
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001302
Product name
MYXOTHIAZOL
Purity
98.00%
Packaging
5MG
Price
$505.27
Updated
2021/12/16
ChemScene
Product number
CS-0043613
Product name
Myxothiazol
Purity
≥99.0%
Packaging
5mg
Price
$730
Updated
2021/12/16
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MYXOTHIAZOL Chemical Properties,Usage,Production

Uses

Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.

Definition

ChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S

Biochem/physiol Actions

Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.

in vivo

Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality[3].

Animal Model:C57Bl/J6 mice[3]
Dosage:0.56 mg/kg
Administration:I.p.; 24 hours intervals for at most 4 times
Result:A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found.

MYXOTHIAZOL Preparation Products And Raw materials

Raw materials

Preparation Products

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MYXOTHIAZOL Suppliers

China 21 Germany 1 South Korea 1 Switzerland 1 United Kingdom 1 United States 6 Global 31
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2815688 13927872512
Fax
0751-8963795
Email
3007421951@qq.com
Country
China
ProdList
9939
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-89903882 18679456698
Email
mingxinzhu@huidabiotech.com
Country
China
ProdList
2975
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
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View Lastest Price from MYXOTHIAZOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Myxothiazol 76706-55-3
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-25

76706-55-3, MYXOTHIAZOLRelated Search:

2-Isopropyl-4-methyl thiazole 3-METHYL-1,5-HEPTADIENE 1,5-HEXADIEN-3-OL 2-Ethyl-4-methyl thiazole 4-METHYL-1-PENTEN-3-OL 2,4-Dimethylthiazole TRANS-2-METHYL-4-HEXEN-3-OL 2-isopropylthiazole 2-ETHYLTHIAZOLE 1,5-HEPTADIEN-4-OL 4-METHYL-1,5-HEPTADIENE MYXOTHIAZOL

  • MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS
  • MYXOTHIAZOL
  • 5-dimethoxy-4-methyl-
  • 7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide
  • myxothiazol from myxobacterium*myxococcus fulvus
  • MYXOTHIAZOL, VIAL WITH 10 MG*
  • MYXOTHIAZOL FROM MYXOBACTERIUM 95%
  • myxothiazolfrommyxobacterium
  • 2,6-Heptadienamide, 7-(2'-((1S,2E,4E)-1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)-
  • 2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
  • Myxothiazo
  • 2,6-Heptadienamide, 7-[2'-[(1S,2E,4E)-1,6-dimethyl-2,4-heptadien-1-yl][2,4'-bithiazol]-4-yl]-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)-
  • 76706-55-3
  • C25H33N3O3S2
  • Antibiotics G-M
  • Antibiotics
  • Antibiotics A to Z
  • BioChemical
  • Inhibits an EnzymeNitric Oxide and Cell Stress
  • Mitochondrial InhibitorsAntibiotics
  • Antibiotics
  • Antibiotics A to
  • Antibiotics G-MAntibiotics
  • AntifungalAntibiotics
  • Cell Stress
  • Chemical Structure Class
  • Mechanism of Action
  • Peptides
  • Spectrum of Activity