MYXOTHIAZOL

Product Name: MYXOTHIAZOL
CAS No.: 76706-55-3
Chemical Name: MYXOTHIAZOL
Synonyms: Myxothiazo;MYXOTHIAZOL;5-dimethoxy-4-methyl-;myxothiazolfrommyxobacterium;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;myxothiazol from myxobacterium*myxococcus fulvus;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
CBNumber: CB0453976
Molecular Formula: C25H33N3O3S2
Formula Weight: 487.68
MOL File: 76706-55-3.mol

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MYXOTHIAZOL Property

Boiling point:: 679.6±65.0 °C(Predicted)
Density: 1.158±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow
pka: 14.07±0.50(Predicted)

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Safety

Hazard Codes: T+
Risk Statements: 28
Safety Statements: 28-36/37-45
RIDADR: UN 3462 6.1/PG 1
WGK Germany: 3
RTECS: QH7580000
F: 10
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T5580
Product name: Myxothiazol
Purity: from Myxococcus fulvus Mx f85, ≥98% (HPLC)
Packaging: 1mg
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: T5580
Product name: Myxothiazol
Purity: from Myxococcus fulvus Mx f85, ≥98% (HPLC)
Packaging: 5mg
Price: $444
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: INB0001302
Product name: MYXOTHIAZOL
Purity: 98.00%
Packaging: 5MG
Price: $505.27
Updated: 2021/12/16

ChemScene

Product number: CS-0043613
Product name: Myxothiazol
Purity: ≥99.0%
Packaging: 5mg
Price: $730
Updated: 2021/12/16

ChemScene

Product number: CS-0043613
Product name: Myxothiazol
Purity: ≥99.0%
Packaging: 1mg
Price: $290
Updated: 2021/12/16

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MYXOTHIAZOL Chemical Properties,Usage,Production

Uses

Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.

Definition

ChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S

Biochem/physiol Actions

Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.

MYXOTHIAZOL Preparation Products And Raw materials

Raw materials

Preparation Products

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MYXOTHIAZOL Suppliers

China 13 Germany 1 South Korea 1 Switzerland 1 United Kingdom 1 United States 6 Global 23

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14059
Advantage: 65

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815688 13927872512
Fax: 0751-8963795
Email: 3007421951@qq.com
Country: China
ProdList: 10071
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 13626641628
Email: jiangnan@huidabiotech.com
Country: China
ProdList: 3661
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223
Email: psaitong@jm-bio.com
Country: China
ProdList: 29834
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-0571-89903882 15990081639
Email: sunshixuan@huidabiotech.com
Country: China
ProdList: 3705
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29803
Advantage: 58

76706-55-3, MYXOTHIAZOLRelated Search:

2-Isopropyl-4-methyl thiazole 3-METHYL-1,5-HEPTADIENE 1,5-HEXADIEN-3-OL 2-Ethyl-4-methyl thiazole 4-METHYL-1-PENTEN-3-OL 2,4-Dimethylthiazole TRANS-2-METHYL-4-HEXEN-3-OL 2-isopropylthiazole 2-ETHYLTHIAZOLE 1,5-HEPTADIEN-4-OL 4-METHYL-1,5-HEPTADIENE MYXOTHIAZOL

MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS

MYXOTHIAZOL

5-dimethoxy-4-methyl-

7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide

myxothiazol from myxobacterium*myxococcus fulvus

MYXOTHIAZOL, VIAL WITH 10 MG*

MYXOTHIAZOL FROM MYXOBACTERIUM 95%

myxothiazolfrommyxobacterium

2,6-Heptadienamide, 7-(2'-((1S,2E,4E)-1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)-

2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-

Myxothiazo

2,6-Heptadienamide, 7-[2'-[(1S,2E,4E)-1,6-dimethyl-2,4-heptadien-1-yl][2,4'-bithiazol]-4-yl]-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)-

76706-55-3

C25H33N3O3S2

Antibiotics G-M

Antibiotics

Antibiotics A to Z

BioChemical

Inhibits an EnzymeNitric Oxide and Cell Stress

Mitochondrial InhibitorsAntibiotics

Antibiotics

Antibiotics A to

Antibiotics G-MAntibiotics

AntifungalAntibiotics

Cell Stress

Chemical Structure Class

Mechanism of Action

Peptides

Spectrum of Activity