Product features Natural astaxanthin Production process Uses Health Benefits of Astaxanthin Side Effects of Astaxanthin Dosage
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Astaxanthin

Product features Natural astaxanthin Production process Uses Health Benefits of Astaxanthin Side Effects of Astaxanthin Dosage
Product Name
Astaxanthin
CAS No.
472-61-7
Chemical Name
Astaxanthin
Synonyms
HAEMATOCOCCUS PLUVIALIS;astaxanthine;Astaxanthin oil;Astaxanthin Powder;BioAstin;Carophyll Pink;HaeMatococcus Powder;all-trans-Astaxanthin;6-Hydroxy-3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[4-hydroxy-2,6,6-trimethyl-3-oxo-1-cyclohexenyl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-2,4,4-trimethyl-1-cyclohex-2-enone;6-hydroxy-3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-(4-hydroxy-2,6,6-trimethyl-3-oxo-1-cyclohexenyl)-3,7,12,16-tetramethyl-octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-2,4,4-trimethyl-cyclohex-2-en-1-one
CBNumber
CB0459594
Molecular Formula
C40H52O4
Formula Weight
596.85
MOL File
472-61-7.mol
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Astaxanthin Property

Melting point:
215-216 °C
Boiling point:
568.55°C (rough estimate)
Density 
0.9980 (rough estimate)
refractive index 
1.4760 (estimate)
storage temp. 
-20°C
solubility 
DMSO: soluble1mg/mL (warmed)
form 
powder
pka
12.33±0.70(Predicted)
color 
pink to very dark purple
Stability:
Light Sensitive
InChIKey
MQZIGYBFDRPAKN-SODZLZBXSA-N
SMILES
C(/C1=C(C(=O)[C@@H](O)CC1(C)C)C)=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C(=O)[C@@H](O)CC1(C)C)C |&1:5,37,r|
LogP
8.163 (est)
CAS DataBase Reference
472-61-7
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
HS Code 
29339990
Hazardous Substances Data
472-61-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
41659
Product name
all-trans-Astaxanthin
Purity
analytical standard
Packaging
1mg
Price
$361
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0982
Product name
Astaxanthin
Purity
≥97% (HPLC), from Blakeslea trispora
Packaging
50mg
Price
$121
Updated
2022/05/15
Cayman Chemical
Product number
70685
Product name
Astaxanthin
Purity
≥97%
Packaging
25mg
Price
$141
Updated
2021/12/16
Cayman Chemical
Product number
70685
Product name
Astaxanthin
Purity
≥97%
Packaging
5mg
Price
$47
Updated
2021/12/16
TRC
Product number
A790025
Product name
Astaxanthin
Packaging
5mg
Price
$55
Updated
2021/12/16
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Astaxanthin Chemical Properties,Usage,Production

Product features

Shrimp flavin is found in river crayfish shell, oysters and salmon, which is a sort of red carotenoid, It can be combined with the protein in vivo and show green, blue. There are antioxidant, anti-aging, anti-tumor, prevention of cardiovascular and cerebrovascular disease.
Astaxanthin is a kind of lutein, the most widely distributed in the animal kingdom. It is pink, and has unique coloring function, also can promote antibody production, enhancing animal immunity. On the aspects of the antioxidant and scavenging free radicals, the ability is stronger than β-carotene( (10 times). It is soluble in water and lipophilic, soluble in carbon disulfide, acetone, benzene and chloroform and other organic solvents. Astaxanthin is a kind of very potential carotenoid additives, and has a broad prospect in food, feed, cosmetics, pharmaceuticals and other fields. Foods which are rich in the astaxanthin include marine plants, Pluvialis microalgae, Phaffia rhodozyma, wild salmon, shrimp, salmon, rainbow trout and other seafood. Astaxanthin can bring many benefits to health, but not everyone can get enough, this is where the problem.

Natural astaxanthin

Natural astaxanthin also known as astacin, is a kind of precious health ingredients, is used for development to enhance immunity, anti-oxidation, anti-inflammatory, eyes and brain health, regulating blood lipids and other natural and healthy products. At present, the main used as a raw material for human health food and medicine; aquaculture (currently the main salmon, trout and salmon), poultry feed additive and additives of cosmetics.
It can significantly improve the body's immunity, because of its non-specific combination with skeletal muscle, can effectively remove the free radicals which are generated by the movement of the muscle cells, strengthen aerobic metabolism, so it has a significant anti fatigue effect.
It is only the carotenoids through blood brain barrier, with true anti-aging effect and effective antioxidant is the basis of all beauty activities. Owing to its powerful antioxidant, It can effectively wrinkle anti-aging, sunscreen whitening and except for chloasma caused by age. In the prevention and treatment for age related macular degeneration and improvement of retinal function, it has good effects. All of the above can clearly be confirmed in the United States.
The stability and antioxidant activity of synthetic astaxanthin also are lower than natural astaxanthin. Because of the hydroxyl (-OH) at ends of the molecule, astaxanthin can be esterification, resulting in not the same of its stability. More than 90% of natural astaxanthin is exist in ester form, and therefore more stable. Synthesic astaxanthin is the free state, therefore, the stability is not the same, must be embedded in order to stabilize. Because Left lateral structure of synthesic astaxanthin was only about 1/4, so it is only natural antioxidant of 1/4.

Production process

A method of production of chitin, astaxanthin, protein, calcium powder and biological fertilizer from shrimp shell, its production process is as follows:
1. The shrimp shell is cleaned and mechanical crushing to 5-10 mesh t.
2. The weight ratio of the shrimp shell powder and the shrimp shell was 1: 1-2, and the protease was added to the solution. According to different varieties of shrimp shell, the temperature of the enzyme solution was 30-70℃, pH value was 4-8, the time was 2-6 hours, and protease was 0.4%-1% of the shrimp shell in weight .
3. After the end of the enzyme solution, the temperature is up to 70-100℃ and then Enzyme bacteria is cool.
4. After that, adding organic solvent extraction, the weight ratio of organic solvent and shrimp shell was 1: 1-2, stirred closed fully 6-12 hours then cooling.
5. After full reaction, separate the liquid of shrimp and shrimp.
6. Shrimp liquid is divided into liquid and organic liquid.

Uses

Natural astaxanthin also known as astacin, is a kind of precious health ingredients, is used for development to enhance immunity, anti-oxidation, anti-inflammatory, eyes and brain health, regulating blood lipids and other natural and healthy products. At present, the main used as a raw material for human health food and medicine; aquaculture (currently the main salmon, trout and salmon), poultry feed additive and additives of cosmetics. It can significantly improve the body's immunity, because of its non-specific combination with skeletal muscle, can effectively remove the free radicals which are generated by the movement of the muscle cells, strengthen aerobic metabolism, so it has a significant anti fatigue effect.

Health Benefits of Astaxanthin

(1) Astaxanthin is a powerful antioxidant. The free radical scavenging activity of astaxanthin protects lipids from peroxidation and reduces oxidative damage of LDL-cholesterol (thereby reducing arterial plaque formation), cells, cell membranes, mitochondrial membranes. Astaxanthin increases strength and endurance.
(2) Astaxanthin seems to improve the immune system by increasing the number of antibody producing cells. Astaxanthin enhances antibody production by exerting actions on T-cells and T-helper cells. Astaxanthin is used to treat neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease.
(3) Astaxanthin protects the eyes and skin from sun radiation damage by quenching singlet and triplet oxygen. Studies with rats show that astaxanthin reduces retinal injury.
(4) Studies have shown the anti-cancer effects of astaxanthin in rodents. The inhibitory effect of astaxanthin on cancer is stronger han that of beta-carotene.

Side Effects of Astaxanthin

You should also know about the side effects of astaxanthin. No toxic side-effects are related with overdose of astaxanthin. However, mild to moderate side effects are noticed with high doses of it. Some side effects include:

  • Aplastic anemia
  • Eye damage because of crystal formation
  • Decreased libido
  • Reduction in blood pressure,
  • Enhanced skin pigmentation
  • Gynecomastia (abnormal enlargement of breasts in men)
  • Inhibited 5-alpha-reductase
  • Increased hair growth
  • Lowered eosinophil counts
  • Parathyroid intervention
  • Lowered serum calcium
  • Inhibited conversion of testosterone to dihydrotestosterone

Dosage

Research has shown that the optimal dosage of astaxanthin is 4 mg per day-which relates to 200 mg of a 2% extract.
It is of prime importance that when evaluating any Astaxanthin supplement that you ensure that you ingest 4 mg PER DAY-which would require 200 mg of a 2% extract-as used in our Anti-Aging Supplement.
Toxicity and symptoms of high intake Astaxanthin
Astaxanthin is practically non-toxic in acute animal studies at doses up to 18 grams. When tested for genotoxicity, there was no evidence for mutagenicity in Ames/Salmonella assays nor did it induce micronuclei when tested in vivo up to 2000 mg/kg in mice. There was no maternal, embryo-toxic or teratogenic effects in a teratology study in rabbits given up to 400 mg/kg over most of the gestational period.
No adverse effects were noted in a one-generation reproduction study at doses up to 400 mg/kg in rats. In multiple subchronic feeding studies in rats, astaxanthin did not produce any adverse toxicological effects.

Chemical Properties

Drak-Purple Solid

Uses

Carotenoid pigment found mostly in animal organisms, but also occuring in plants; thought to be the precursor of astacin. Animal studies indicate that it reduces blood glucose and ameliorates several parameters of the diabetic metabolic syndrome. It improves blood flow and vascular tone in models of hypertension.

Uses

Astaxanthin is a carotenoid pigment found primarily in marine animals including shrimp and salmon. It is a potent lipid-soluble antioxidant.

Uses

astaxanthin is an anti-oxidant. Molecularly, astaxanthin is similar to beta-carotene, but in clinical studies it appears to demonstrate stronger anti-oxidant properties, including an ability to inhibit lipid peroxidation and an anti-inflammatory capacity. It is used in cosmetics for its anti-oxidant properties, and for possible uV protection abilities. Astaxanthin is a naturally occurring pigment, part of the carotenoid group, and found in many foods. It is what provides salmon and certain crustaceans (e.g., shrimp, crab, lobster) with their reddish tint. Astaxanthin can also be synthetically produced.

Definition

ChEBI: Astaxanthin is a carotenone that consists of beta,beta-carotene-4,4'-dione bearing two hydroxy substituents at positions 3 and 3' (the 3S,3'S diastereomer). A carotenoid pigment found mainly in animals (crustaceans, echinoderms) but also occurring in plants. It can occur free (as a red pigment), as an ester, or as a blue, brown or green chromoprotein. It has a role as an anticoagulant, an antioxidant, a food colouring, a plant metabolite and an animal metabolite. It is a carotenone and a carotenol. It derives from a hydride of a beta-carotene.

Biotechnological Production

Commercial production processes are known in which astaxanthin production is performed in closed photobioreactors by Cyanotech Corporation (Hawaii). This mode of cultivation strongly improves process control, algae predation, and production, but the fermentation costs are significantly higher. These higher costs have to be compensated by high productivity levels and more efficient downstream processing in order to make a competitive product.
Most of the astaxanthin available on the world market has been produced chemically since the 1950s, for example, by DSM and BASF, and the process is efficient and cost-effective. There are also microbial sources, for example, X. dendrorhous (previously described as P. rhodozyma), and the alga H. pluvialis. X. dendrorhous has been widely investigated as to its potential of astaxanthin production for salmonids. This has resulted in a race between companies in the 1980s and 1990s. Natural astaxanthin is currently available as a spray-dried powder (5–10 mg astaxanthin/g), and is supplemented to fish feed to give salmonid flesh its pink color. Another astaxanthin application is in the nutraceutical market, as astaxanthin is regarded as a potential antioxidant. With regard to production by algae, H. pluvialis is the only species commercially cultivated for astaxanthin production. This green alga is able to grow under autotrophic, heterotrophic, and mixotrophic conditions. An example of the latter is its ability to grow in the presence of acetate and light. Astaxanthin accumulates in response to stress in lipid globules of the cells.

General Description

all-trans-Astaxanthin is a ketocarotenoid, most commonly identified in marine and aquatic animals, including krill, wild salmon, rainbow trout, microalgae, shells of lobster, shrimp, seafood products, etc. It is biologically known as a vitamin A precursor, and exhibits strong antioxidant property, much higher compared to vitamin E and β-carotene. Its role in food and the medicinal industry is also well-defined.

Biochem/physiol Actions

Astaxanthin is a potent carotenoid antioxidant found in marine algae, red yeast and many other plant and animal sources. Animal studies indicate that it reduces blood glucose and ameliorates several parameters of the diabetic metabolic syndrome. It improves blood flow and vascular tone in models of hypertension. In vitro studies indicate that it upregulates connexin 43 and thus, may be chemopreventive against cancer.

Astaxanthin Preparation Products And Raw materials

Raw materials

Preparation Products

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Astaxanthin Suppliers

Shaanxi Pioneer Biotech Co., Ltd
Tel
029-86616368 18123784671
Email
sales@pioneerbiotech.com
Country
China
ProdList
500
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
400-400-400-9004166 18117592386
Email
3007522982@qq.com
Country
China
ProdList
52712
Advantage
58
Xi`an Tian Guangyuan Biotech Co., Ltd.
Tel
17391926474
Email
2539013658@qq.com
Country
China
ProdList
205
Advantage
58
Suzhou NMT Biotech Co., Ltd.
Tel
0512-62388427 2403880319 18012730781
Fax
QQ2403880319
Email
longchengnmt@gmail.com
Country
China
ProdList
25
Advantage
58
Shengbaolai Biotechnology Co., Ltd
Tel
027-59105235 15527244834
Email
shengblai@126.com
Country
China
ProdList
500
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24835
Advantage
65
Wuxi Jingyao Bio-Technology Co., Ltd.
Tel
0510-88770633 13961738808
Email
jingyaobiotech@126.com
Country
China
ProdList
301
Advantage
55
Vertexyn (Nanjing) Bioworks Co., Ltd.
Tel
025-58822206 18020175818
Email
sales@vertexynbio.com
Country
China
ProdList
10
Advantage
58
Sanyuan Tianyu Biological Products Co., Ltd
Tel
17765811106
Email
1053528223@qq.com
Country
China
ProdList
1005
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from Astaxanthin manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
Astaxanthin 472-61-7
Price
US $0.00-0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
200000
Release date
2023-08-15
Hebei Yime New Material Technology Co., Ltd.
Product
astaxanthin 472-61-7
Price
US $270.00/KG
Min. Order
1KG
Purity
1% 5% 10%
Supply Ability
1000kg/month
Release date
2023-11-16
Sinoway Industrial co., ltd.
Product
Nanoactive Astaxanthin 472-61-7
Price
US $280.00-160.00/KG
Min. Order
1KG
Purity
5% by HPLC
Supply Ability
20 tons
Release date
2024-01-02

472-61-7, AstaxanthinRelated Search:


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