4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE

Product Name: 4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE
CAS No.: 209480-63-7
Chemical Name: 4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE
Synonyms: SB258585HCl;SB 258585 hydrochlor;SB 258585 HYDROCHLORIDE;Benzenesulfonamide, 4-iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-;4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE
CBNumber: CB0461021
Molecular Formula: C18H22IN3O3S
Formula Weight: 487.36
MOL File: 209480-63-7.mol

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4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE Property

storage temp.: 2-8°C
solubility: DMF: 15 mg/mL
DMSO: 20 mg/mL
Ethanol: 0.25 mg/mLPBS (pH 7.2): 10 mg/mL
form: solid
color: off-white

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-42/43
Safety Statements: 26-36/37-45
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1961
Product name: SB258585hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $191
Updated: 2021/12/16

Tocris

Product number: 1961
Product name: SB258585hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $802
Updated: 2021/12/16

TRC

Product number: S155038
Product name: SB258585
Packaging: 10mg
Price: $130
Updated: 2021/12/16

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4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

SB 258585 is a selective and potent SR-6 and 5-HT6R antagonist.

Biological Activity

Potent and selective 5-HT 6 receptor antagonist (pK i = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.

References

[1] WARREN D HIRST. Characterization of [125I]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue[J]. British Journal of Pharmacology, 2009, 130 7: 1597-1605. DOI: 10.1038/sj.bjp.0703458
[2] CAROL ROUTLEDGE. Characterization of SB-271046: A potent, selective and orally active 5-HT6 receptor antagonist[J]. British Journal of Pharmacology, 2009, 130 7: 1606-1612. DOI: 10.1038/sj.bjp.0703457
[3] AYAKA TATARA. Modulation of antipsychotic-induced extrapyramidal side effects by medications for mood disorders[J]. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2012, 38 2: Pages 252-259. DOI: 10.1016/j.pnpbp.2012.04.008
[4] FANNY DUHR. Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth[J]. Nature chemical biology, 2014, 10 7: 590-597. DOI: 10.1038/nchembio.1547
[5] SAKI SHIMIZU. Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice[J]. Journal of pharmacological sciences, 2015, 127 4: Pages 439-445. DOI: 10.1016/j.jphs.2015.03.004

4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE Suppliers

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209480-63-7, 4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDERelated Search:

4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE 1-(5-AMINO-2-METHOXYPHENYL)PIPERAZINE 4-IODO-N-[4-METHOXY-3-(4-METHYLPIPERAZIN-1-YL)PHENYL]BENZENE-SULFONAMIDE DIHYDROCHLORIDE 1-(5-AMINO-2-METHOXYPHENYL)-4-METHYLPIPERAZINE

4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE

SB 258585 HYDROCHLORIDE

SB258585HCl

Benzenesulfonamide, 4-iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-

SB 258585 hydrochlor

209480-63-7

C18H22IN3O3SHCl